Lewit-Bentley A, Réty S
Laboratoire pour l'Utilisation du Rayonnement Electromagnétique (LURE), CNRS, CEA, MRT, Centre Universitaire Paris-Sud, BP 34, 91898 Cedex, Orsay, France.
Curr Opin Struct Biol. 2000 Dec;10(6):637-43. doi: 10.1016/s0959-440x(00)00142-1.
The EF-hand motif is the most common calcium-binding motif found in proteins. Several high-resolution structures containing different metal ions bound to EF-hand sites have given new insight into the modulation of their binding affinities. Recently determined structures of members of several newly identified protein families that contain the EF-hand motif in some of their domains, as well as of their complexes with target molecules, are throwing light on the surprising variety of functions that can be served by this simple and ingenious structural motif.
EF 手型基序是蛋白质中最常见的钙结合基序。几个含有与 EF 手型位点结合的不同金属离子的高分辨率结构，为其结合亲和力的调节提供了新的见解。最近确定的几个新鉴定的蛋白质家族成员的结构，这些家族在其某些结构域中含有 EF 手型基序，以及它们与靶分子的复合物结构，正在揭示这个简单而巧妙的结构基序所能发挥的惊人多样的功能。
