Chessick K C, Begley L A, Curtis L E, Hirsch E F, Kaiser C W, Burek C A, Soroff H S
Ann Surg. 1975 Feb;181(2):203-6. doi: 10.1097/00000658-197502000-00014.
In a comparative study on a general surgical service, intravenous clindamycin phosphate or methicillin was used to treat a variety of soft tissue infections due to gram-positive organisms, chiefly staphylococci. The infections were rated according to severity, responsible organisms, and site of the infection. Excellent or good clinical and bacteriologic responses were obtained with both clindamycin and methicillin as adjuncts to basic surgical therapy in these soft tissue infections. The adverse effects of each drug were detailed, and were comparable. Clindamycin phosphate is a satisfactory substitute for methicillin in soft tissue infections secondary to gram-positive organisms.
在一项针对普通外科服务的对比研究中，静脉注射磷酸克林霉素或甲氧西林被用于治疗由革兰氏阳性菌（主要是葡萄球菌）引起的多种软组织感染。根据感染的严重程度、致病微生物及感染部位对这些感染进行评级。在这些软组织感染中，将克林霉素和甲氧西林作为基本外科治疗的辅助药物，均获得了良好或优秀的临床及细菌学疗效。详细阐述了每种药物的不良反应，且二者具有可比性。在革兰氏阳性菌引起的软组织感染中，磷酸克林霉素是甲氧西林的一种令人满意的替代药物。
