Carlisle H N, Saslaw S
Antimicrob Agents Chemother. 1972 Jun;1(6):460-5. doi: 10.1128/AAC.1.6.460.
Intravenous inoculation of a group A hemolytic streptococcus caused lethal infections in all of eight untreated monkeys. Intramuscular injections of clindamycin-2-phosphate in a daily dose of 25 mg/kg given in equal morning and afternoon doses for 10 days resulted in survival of all of eight monkeys. Similar results were observed with the same dose schedule of clindamycin hydrochloride given intragastrically; no fatalities occurred among eight monkeys. In monkeys receiving erythromycin stearate intragastrically or methicillin intramuscularly, three of eight and four of eight monkeys, respectively, died. Duration of both illness and positive blood cultures was greater in the erythromycin- and methicillin-treated survivors than in the clindamycin-treated monkeys. The differences in results between clindamycin and erythromycin could not be correlated with serum antibacterial activity levels, which were similar, or with minimal inhibitory concentrations, which were 0.02 mug/ml with both antibiotics. With methicillin, however, the minimal inhibitory concentration was 0.16 mug/ml and serum antibacterial activity varied from titers of less than 1:2 to 1:8. As in previous studies of staphylococcal infections in monkeys with the same antibiotics, in vitro susceptibility data and serum antibacterial activity did not completely correlate with in vivo results.
给一组猴子静脉注射 A 组溶血性链球菌，8 只未经治疗的猴子全部发生致死性感染。给另外 8 只猴子每日分上午和下午等量注射磷酸克林霉素，剂量为 25mg/kg，共注射 10 天，所有 8 只猴子均存活。给 8 只猴子按相同剂量方案灌胃盐酸克林霉素，观察到相似结果；8 只猴子均未死亡。给猴子灌胃硬脂酸红霉素或肌肉注射甲氧西林，8 只猴子中分别有 3 只和 4 只死亡。接受红霉素和甲氧西林治疗的存活猴子的病程和血培养阳性时间均长于接受克林霉素治疗的猴子。克林霉素和红霉素治疗结果的差异与血清抗菌活性水平无关（二者相似），也与最低抑菌浓度无关（两种抗生素的最低抑菌浓度均为 0.02μg/ml）。然而，甲氧西林的最低抑菌浓度为 0.16μg/ml，血清抗菌活性的效价从低于 1:2 到 1:8 不等。与之前用相同抗生素对猴子进行葡萄球菌感染的研究一样，体外药敏数据和血清抗菌活性与体内结果并不完全相关。
