Cullen P J, Chardin P
Department of Biochemistry, University of Bristol, BS8 1TD,., Bristol, UK.
Curr Biol. 2000 Nov 30;10(23):R876-8. doi: 10.1016/s0960-9822(00)00818-6.
Pleckstrin homology domains are modular domains that direct membrane targeting of their host proteins by binding to polyphosphoinositides; recent results have increased our appreciation of how some of these domains actually bind 3-phosphoinositides, and along the way thrown up some unexpected observations.
