Dodelet V C, Pasquale E B
The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California, CA 92037, USA.
Oncogene. 2000 Nov 20;19(49):5614-9. doi: 10.1038/sj.onc.1203856.
Protein tyrosine kinase genes are the largest family of oncogenes. This is not surprising since tyrosine kinases are important components of signal transduction pathways that control cell shape, proliferation, differentiation, and migration. At 14 distinct members, the Eph kinases constitute the largest family of receptor tyrosine kinases. Although they have been most intensively studied for their roles in embryonic development, increasing evidence also implicates Eph family proteins in cancer. This review will address the recent progress in understanding the function of Eph receptors in normal development and how disregulation of these functions could promote tumorigenesis.
蛋白质酪氨酸激酶基因是癌基因中最大的家族。这并不奇怪，因为酪氨酸激酶是信号转导通路的重要组成部分，这些通路控制细胞形态、增殖、分化和迁移。Eph激酶有14个不同的成员，构成了受体酪氨酸激酶中最大的家族。尽管它们在胚胎发育中的作用得到了最深入的研究，但越来越多的证据也表明Eph家族蛋白与癌症有关。这篇综述将阐述在理解Eph受体在正常发育中的功能以及这些功能失调如何促进肿瘤发生方面的最新进展。
