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在胃肠道癌中：表达、调控及临床意义。

in gastrointestinal cancer: Expression, regulation and clinical significance.

作者信息

Chu Ling-Yu, Huang Bin-Liang, Huang Xu-Chun, Peng Yu-Hui, Xie Jian-Jun, Xu Yi-Wei

机构信息

Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, Guangdong Province, China.

Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, Shantou 515041, Guangdong Province, China.

出版信息

World J Gastrointest Oncol. 2022 May 15;14(5):973-988. doi: 10.4251/wjgo.v14.i5.973.

DOI:10.4251/wjgo.v14.i5.973
PMID:35646281
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9124989/
Abstract

Ephrin-A1 is a protein that in humans is encoded by the gene. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases which play an indispensable role in normal growth and development or in the pathophysiology of various tumors. The role of in tumorigenesis and development is complex and depends on the cell type and microenvironment which in turn affect the expression of . This article reviews the expression, prognostic value, regulation and clinical significance of in gastrointestinal tumors.

摘要

Ephrin-A1是一种在人类中由该基因编码的蛋白质。ephrin和EPH相关受体构成了受体蛋白酪氨酸激酶的最大亚家族，它们在正常生长发育或各种肿瘤的病理生理学中发挥着不可或缺的作用。其在肿瘤发生和发展中的作用是复杂的，并且取决于细胞类型和微环境，而细胞类型和微环境又反过来影响其表达。本文综述了其在胃肠道肿瘤中的表达、预后价值、调控及临床意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d9b/9124989/6beb4b436e83/WJGO-14-973-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d9b/9124989/2c9c06436cd3/WJGO-14-973-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d9b/9124989/1eebe89dafff/WJGO-14-973-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d9b/9124989/6beb4b436e83/WJGO-14-973-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d9b/9124989/2c9c06436cd3/WJGO-14-973-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d9b/9124989/1eebe89dafff/WJGO-14-973-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d9b/9124989/6beb4b436e83/WJGO-14-973-g003.jpg

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Int J Mol Sci. 2021 Mar 1;22(5):2480. doi: 10.3390/ijms22052480.
2
Targeting EphA2 in cancer.靶向 EphA2 治疗癌症。
J Hematol Oncol. 2020 Aug 18;13(1):114. doi: 10.1186/s13045-020-00944-9.
3
Role of EFNA1 in tumorigenesis and prospects for cancer therapy.EFNA1 在肿瘤发生中的作用及癌症治疗的前景。
Rapid cyclic stretching induces a synthetic, proinflammatory phenotype in cultured human intestinal smooth muscle, with the potential to alter signaling to adjacent bowel cells.
快速周期性拉伸可诱导培养的人肠道平滑肌产生一种合成性促炎表型，有可能改变向相邻肠细胞的信号传导。
bioRxiv. 2024 Oct 15:2024.10.12.617767. doi: 10.1101/2024.10.12.617767.
4
Combined detection of serum EFNA1 and MMP13 as diagnostic biomarker for gastric cancer.联合检测血清 EFNA1 和 MMP13 作为胃癌的诊断生物标志物。
Sci Rep. 2024 Jul 10;14(1):15957. doi: 10.1038/s41598-024-65839-y.
5
Ephs in cancer progression: complexity and context-dependent nature in signaling, angiogenesis and immunity.Eph 家族在癌症进展中的作用：信号转导、血管生成和免疫中的复杂性和上下文依赖性。
Cell Commun Signal. 2024 May 29;22(1):299. doi: 10.1186/s12964-024-01580-3.
6
Comparative transcriptome characterization of esophageal squamous cell carcinoma and adenocarcinoma.食管鳞状细胞癌和腺癌的比较转录组特征分析
Comput Struct Biotechnol J. 2023 Jul 25;21:3841-3853. doi: 10.1016/j.csbj.2023.07.030. eCollection 2023.
Biomed Pharmacother. 2020 Oct;130:110567. doi: 10.1016/j.biopha.2020.110567. Epub 2020 Jul 31.
4
Therapeutic Targeting of Pancreatic Cancer via EphA2 Dimeric Agonistic Agents.通过EphA2二聚体激动剂对胰腺癌进行治疗靶向
Pharmaceuticals (Basel). 2020 May 10;13(5):90. doi: 10.3390/ph13050090.
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Onco Targets Ther. 2019 Oct 14;12:8491-8499. doi: 10.2147/OTT.S213252. eCollection 2019.
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Mol Med Rep. 2019 Oct;20(4):3649-3660. doi: 10.3892/mmr.2019.10608. Epub 2019 Aug 23.
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