Hunan Key Laboratory of Early Diagnosis and Precise Treatment of Lung Cancer, the Second Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Cell Commun Signal. 2024 May 29;22(1):299. doi: 10.1186/s12964-024-01580-3.
Eph receptors constitute the largest family of receptor tyrosine kinases, comprising 14 distinct members classified into two subgroups: EphAs and EphBs.. Despite their essential functions in normal physiological processes, accumulating evidence suggests that the involvement of the Eph family in cancer is characterized by a dual and often contradictory nature. Research indicates that Eph/ephrin bidirectional signaling influences cell-cell communication, subsequently regulating cell migration, adhesion, differentiation and proliferation. The contradictory functionalities may arise from the diversity of Eph signaling pathways and the heterogeneity of different cancer microenvironment. In this review, we aim to discuss the dual role of the Eph receptors in tumor development, attempting to elucidate the paradoxical functionality through an exploration of Eph receptor signaling pathways, angiogenesis, immune responses, and more. Our objective is to provide a comprehensive understanding of the molecular mechanisms underlying tumor development. Additionally, we will explore the evolving landscape of utilizing Eph receptors as potential targets for tumor therapy and diagnostic tools.
Eph 受体构成了受体酪氨酸激酶家族中最大的家族，包括 14 个不同的成员，分为两个亚群：EphA 和 EphB。尽管它们在正常生理过程中具有重要功能，但越来越多的证据表明 Eph 家族在癌症中的参与具有双重性，且往往具有矛盾性。研究表明，Eph/ephrin 双向信号影响细胞间通讯，从而调节细胞迁移、黏附、分化和增殖。这种矛盾的功能可能源于 Eph 信号通路的多样性和不同癌症微环境的异质性。在这篇综述中，我们旨在讨论 Eph 受体在肿瘤发展中的双重作用，试图通过探索 Eph 受体信号通路、血管生成、免疫反应等，阐明 Eph 受体信号通路的矛盾功能。我们的目的是提供对肿瘤发展背后的分子机制的全面理解。此外，我们还将探讨利用 Eph 受体作为肿瘤治疗和诊断工具的潜在靶点的不断发展的前景。
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