Gleeson M, Francis J L, Lugg D J, Clancy R L, Ayton J M, Reynolds J A, McConnell C A
Hunter Immunology Unit, Royal Newcastle Hospital, New South Wales, Australia.
Immunol Cell Biol. 2000 Dec;78(6):616-22. doi: 10.1046/j.1440-1711.2000.00958.x.
The effect of a year's isolation in Antarctica on the human mucosal immune system was assessed during the winter of 1992 at three Australian Antarctic stations: Casey, Davis and Mawson. Saliva samples were collected from each expeditioner prior to their departure from Australia and during each month in Antarctica. The concentrations of salivary immunoglobulins IgA and IgG were significantly different between the three stations, but there were no differences for salivary IgM and albumin. The mean concentrations of IgA were higher at Mawson (P < 0.008), and the mean concentrations of IgG were lower at Davis (P < 0.001) compared with the other stations. Ranges of values observed at the stations over the 12-13 months were similar. The variability of values within individuals showed station differences for salivary IgM and IgG only. The study revealed significant changes in salivary immunoglobulin values over the period in Antarctica, with similar patterns at the three Australian stations. The salivary IgA and IgM levels were lower in the first 4 months in Antarctica (January-April) and increased to maximum values in July-August, before returning to mean levels when isolation was broken in October-November. The patterns of salivary IgA and IgM suggest that stressors due to isolation may play a role in alterations of mucosal immunity in expeditioners in Antarctica.
1992年冬季，在澳大利亚的三个南极考察站——凯西、戴维斯和莫森，评估了在南极洲隔离一年对人类黏膜免疫系统的影响。在每位考察队员离开澳大利亚之前以及在南极洲的每个月，都采集了唾液样本。三个考察站唾液免疫球蛋白IgA和IgG的浓度存在显著差异，但唾液IgM和白蛋白没有差异。与其他考察站相比，莫森的IgA平均浓度更高（P < 0.008），戴维斯的IgG平均浓度更低（P < 0.001）。在12至13个月期间，各考察站观察到的值范围相似。个体内的值变异性仅在唾液IgM和IgG方面表现出考察站差异。该研究揭示了在南极洲期间唾液免疫球蛋白值的显著变化，澳大利亚的三个考察站呈现出相似的模式。唾液IgA和IgM水平在南极洲的前4个月（1月至4月）较低，在7月至8月升至最大值，在10月至11月隔离结束恢复到平均水平之前。唾液IgA和IgM的模式表明，隔离带来的压力源可能在南极洲考察队员黏膜免疫的改变中起作用。
