Norhagen Engström G, Engström P E
Department of Periodontology, Faculty of Odontology, Karolinska Institute, Huddinge Hospital, Sweden.
Eur J Oral Sci. 1998 Dec;106(6):986-91. doi: 10.1046/j.0909-8836.1998.eos106602.x.
Salivary immunoglobulins and albumin were analysed in smoking and non-smoking immunocompetent and immunodeficient individuals. Stimulated and unstimulated saliva were compared as between individuals with selective immunoglobulin A deficiency (IgAd), common variable immunodeficiency (CVI) and immunocompetent individuals. Immunocompetent smokers showed increased levels of sIgA in unstimulated saliva, when compared with non-smoking immunocompetent individuals. In stimulated saliva, the immunocompetent smokers showed decreased levels of IgG and IgM. IgAd smokers showed decreased levels of albumin in unstimulated saliva, when compared with non-smoking IgAd individuals. The non-smoking individuals with IgAd showed increased levels of IgM in both unstimulated and stimulated saliva, when compared with immunocompetent smokers. The non-smoking CVI individuals showed decreased levels of IgG, IgA and IgM in unstimulated and stimulated saliva, as expected, when compared with the same group of immunocompetent individuals. The decreased levels of albumin in unstimulated saliva in IgAd smokers and comparable to that of the IgG non-smoking IgAd individuals support the observation of locally produced immunoglobulins that protect the oral mucosa. Instead of sIgA, non-smoking immunodeficient individuals with IgAd compensate with increased IgM levels in stimulated saliva. The increased levels of sIgA in unstimulated saliva in immunocompetent smokers may be a reflection of the protection of the oral mucosa.
对吸烟和不吸烟的免疫功能正常及免疫缺陷个体的唾液免疫球蛋白和白蛋白进行了分析。比较了选择性免疫球蛋白A缺乏症（IgAd）、常见可变免疫缺陷（CVI）个体以及免疫功能正常个体在刺激唾液和未刺激唾液中的情况。与不吸烟的免疫功能正常个体相比，免疫功能正常的吸烟者未刺激唾液中的分泌型免疫球蛋白A（sIgA）水平升高。在刺激唾液中，免疫功能正常的吸烟者的免疫球蛋白G（IgG）和免疫球蛋白M（IgM）水平降低。与不吸烟的IgAd个体相比，IgAd吸烟者未刺激唾液中的白蛋白水平降低。与免疫功能正常的吸烟者相比，不吸烟的IgAd个体在未刺激和刺激唾液中的IgM水平均升高。正如预期的那样，与同一组免疫功能正常个体相比，不吸烟的CVI个体在未刺激和刺激唾液中的IgG、IgA和IgM水平均降低。IgAd吸烟者未刺激唾液中白蛋白水平的降低以及与不吸烟的IgAd个体中IgG水平的降低相当，支持了局部产生的免疫球蛋白保护口腔黏膜的观察结果。不吸烟的IgAd免疫缺陷个体在刺激唾液中用升高的IgM水平替代sIgA。免疫功能正常的吸烟者未刺激唾液中sIgA水平的升高可能反映了对口腔黏膜的保护作用。
