Young E A, Midgley A R, Carlson N E, Brown M B
Mental Health Research Institute, 205 Zina Pitcher Place, Ann Arbor, MI 48109, USA.
Arch Gen Psychiatry. 2000 Dec;57(12):1157-62. doi: 10.1001/archpsyc.57.12.1157.
Stress and corticotropin-releasing hormone inhibit the reproductive axis. We hypothesized that reproductive axis hormone secretion, particularly luteinizing hormone secretion, is inhibited in women with depression, similar to what has been observed to be caused by stress in numerous species.
Blood samples were collected every 10 minutes for 12 hours in 25 untreated premenopausal women with depression and 25 nondepressed women who were matched by age and menstrual cycle day. Samples were assayed for luteinizing hormone, follicle-stimulating hormone, estradiol, and progesterone.
The mean plasma estradiol level was 30% lower in the follicular phase in women with depression than in their matched controls: 191 + 136 vs 261 + 169 pmol/L (52 + 37 vs 71 + 46 pg/mL). The half-life of luteinizing hormone was significantly shorter in women with depression than in their matched controls during both the follicular (22% shorter) and luteal (15% shorter) phases.
The blood levels of reproductive hormones were mostly normal in women with depression, but the blood level of estradiol was significantly lower. Estradiol is known to affect a number of neurotransmitter systems in the brain. Arch Gen Psychiatry. 2000;57:1157-1162.
应激和促肾上腺皮质激素释放激素会抑制生殖轴。我们假设，抑郁症女性的生殖轴激素分泌，尤其是促黄体生成素的分泌会受到抑制，这与在众多物种中观察到的应激所致情况类似。
对25名未接受治疗的绝经前抑郁症女性和25名年龄及月经周期日相匹配的非抑郁症女性，每10分钟采集一次血样，共采集12小时。对血样进行促黄体生成素、促卵泡激素、雌二醇和孕酮检测。
抑郁症女性在卵泡期的平均血浆雌二醇水平比匹配的对照组低30%：分别为191 + 136与261 + 169 pmol/L（52 + 37与71 + 46 pg/mL）。在卵泡期（短22%）和黄体期（短15%），抑郁症女性促黄体生成素的半衰期均显著短于匹配的对照组。
抑郁症女性的生殖激素血水平大多正常，但雌二醇血水平显著较低。已知雌二醇会影响大脑中的多种神经递质系统。《美国医学会杂志·精神病学卷》。2000年；57:1157 - 1162。
