Yilmaz G, Akova Y, Aydin P
Başkent University School of Medicine, Department of Ophthalmology, Ankara, Turkey.
Eye (Lond). 2000 Oct;14 Pt 5:717-20. doi: 10.1038/eye.2000.190.
To report macular ischaemia and visual loss in patients with panuveitis due to Behçet's disease.
We describe macular ischaemia, a rare finding, in 3 eyes of 3 patients with panuveitis who were diagnosed and treated as having Behçet's disease. The patients underwent fundus fluorescein angiography (FFA) using a digital imaging system and were treated with topical and oral steroids and cyclosporine in 2 cases, and with added azathioprine in the third case.
The 3 eyes showed macular ischaemia associated with peripheral retinal vasculitis on FFA and control of inflammation was achieved in all cases. After an average of 2 years follow-up, visual acuity and macular ischaemia improved in 2 eyes, while no recovery was seen in the third.
The presence of macular ischaemia on FFA in Behçet's disease is a predictor of poor visual outcome. Macular ischaemia may show partial recovery with the treatment of the disease.
报告白塞病所致全葡萄膜炎患者的黄斑缺血和视力丧失情况。
我们描述了3例全葡萄膜炎患者的3只眼中出现的黄斑缺血这一罕见发现，这些患者被诊断为白塞病并接受了相应治疗。患者使用数字成像系统进行了眼底荧光血管造影（FFA），2例患者接受了局部和口服类固醇及环孢素治疗，第3例患者在此基础上加用了硫唑嘌呤。
3只眼在FFA上显示黄斑缺血并伴有周边视网膜血管炎，所有病例的炎症均得到控制。平均随访2年后，2只眼的视力和黄斑缺血情况有所改善，而第3只眼未见恢复。
白塞病患者FFA上出现黄斑缺血是视力预后不良的一个预测指标。黄斑缺血可能会随着疾病的治疗而部分恢复。
