Abebe A, Pollakis G, Fontanet A L, Fisseha B, Tegbaru B, Kliphuis A, Tesfaye G, Negassa H, Cornelissen M, Goudsmit J, Rinke de Wit T F
Ethiopian-Netherlands AIDS Research Project (ENARP) at the Ethiopian Health and Nutrition Research Institute (EHNRI), Addis Ababa.
AIDS Res Hum Retroviruses. 2000 Nov 20;16(17):1909-14. doi: 10.1089/08892220050195865.
Others and we have previously shown that subtype C is the predominant HIV-1 subtype and the major cause of AIDS in Ethiopia. The present study shows that subtype C in Ethiopia has a genetic subcluster, designated C', has not increased in frequency, or spread geographically, over the period 1988 (%C' = 23/53) to 1996-1997 (%C' = 26/50). There is no association of the HIV-1 subtype C or subcluster C' with geographic location, time of sample collection, or risk group in Ethiopia. Of 105 randomly collected samples representing 7 different towns in Ethiopia, all but 2 (1 subtype A from Addis Ababa, 1997 and 1 subtype D from Dessie, 1996) belong to subtype C.
我们和其他人之前已经表明，C亚型是埃塞俄比亚主要的HIV-1亚型，也是导致艾滋病的主要原因。本研究表明，埃塞俄比亚的C亚型有一个名为C'的基因亚群，在1988年（C'占比=23/53）至1996 - 1997年（C'占比=26/50）期间，其频率未增加，在地理上也未扩散。在埃塞俄比亚，HIV-1 C亚型或C'亚群与地理位置、样本采集时间或风险组之间没有关联。在随机收集的代表埃塞俄比亚7个不同城镇的105个样本中，除了2个样本（1997年来自亚的斯亚贝巴的1个A亚型样本和1996年来自德西的1个D亚型样本）外，其余均属于C亚型。
