Traver D, Akashi K, Manz M, Merad M, Miyamoto T, Engleman E G, Weissman I L
Department of Pathology, Stanford University, Stanford, CA 94305, USA.
Science. 2000 Dec 15;290(5499):2152-4. doi: 10.1126/science.290.5499.2152.
Dendritic cells (DCs) are critical in both initiating adaptive immune responses and maintaining tolerance to self antigens. These apparently contradictory roles have been suggested to depend on different subsets of DCs that arise from either myeloid or lymphoid hematopoietic origins, respectively. Although DC expression of CD8alpha is attributed to a lymphoid origin, here we show that both CD8alpha+ and CD8alpha- DCs can arise from clonogenic common myeloid progenitors in both thymus and spleen. Thus, expression of CD8alpha is not indicative of a lymphoid origin, and phenotypic and functional differences among DC subsets are likely to reflect maturation status rather than ontogeny.
树突状细胞（DCs）在启动适应性免疫反应和维持对自身抗原的耐受性方面都起着关键作用。有人提出，这些明显相互矛盾的作用取决于分别源自髓系或淋巴系造血起源的不同DC亚群。尽管CD8α的DC表达归因于淋巴系起源，但我们在此表明，CD8α+和CD8α-DCs都可源自胸腺和脾脏中的克隆性共同髓系祖细胞。因此，CD8α的表达并不表明是淋巴系起源，DC亚群之间的表型和功能差异可能反映的是成熟状态而非个体发生。
