先天淋巴细胞和树突状细胞发育的共调控。

Shared Transcriptional Control of Innate Lymphoid Cell and Dendritic Cell Development.

机构信息

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63108, USA; email:

Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri 63108, USA.

出版信息

Annu Rev Cell Dev Biol. 2019 Oct 6;35:381-406. doi: 10.1146/annurev-cellbio-100818-125403. Epub 2019 Jul 5.

DOI:10.1146/annurev-cellbio-100818-125403

PMID:31283378

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6886469/

Abstract

Innate immunity and adaptive immunity consist of highly specialized immune lineages that depend on transcription factors for both function and development. In this review, we dissect the similarities between two innate lineages, innate lymphoid cells (ILCs) and dendritic cells (DCs), and an adaptive immune lineage, T cells. ILCs, DCs, and T cells make up four functional immune modules and interact in concert to produce a specified immune response. These three immune lineages also share transcriptional networks governing the development of each lineage, and we discuss the similarities between ILCs and DCs in this review.

摘要

先天免疫和适应性免疫由高度特化的免疫谱系组成，这些谱系的功能和发育都依赖于转录因子。在这篇综述中，我们剖析了两个先天免疫谱系（固有淋巴细胞 (ILC) 和树突状细胞 (DC)）和一个适应性免疫谱系（T 细胞）之间的相似性。ILC、DC 和 T 细胞组成了四个功能免疫模块，它们协同作用以产生特定的免疫反应。这三个免疫谱系还共享调控每个谱系发育的转录网络，我们在这篇综述中讨论了 ILC 和 DC 之间的相似性。