Stabel J R
USDA-ARS, National Animal Disease Center, Ames, IA 50010, USA.
Vet Microbiol. 2000 Dec 20;77(3-4):465-73. doi: 10.1016/s0378-1135(00)00331-x.
The host immune response to infection with Mycobacterium paratuberculosis is paradoxical, with strong cell-mediated immune responses during the early, subclinical stages of infection and strong humoral responses during the late clinical stages of the disease. Cell-mediated immune responses modulated by various T cell subsets are essential to provide protective immunity and prevent progression of the disease. Secretion of cytokines by T cell populations serves to activate macrophages to kill ingested M. paratuberculosis as well as activate other T cell subsets to contain the infection. This paper reviews the current knowledge of T cell immune responses in M. paratuberculosis infection based upon clinical studies and research using mouse models.
宿主对副结核分枝杆菌感染的免疫反应是矛盾的，在感染的早期亚临床阶段有强烈的细胞介导免疫反应，而在疾病的晚期临床阶段有强烈的体液免疫反应。由各种T细胞亚群调节的细胞介导免疫反应对于提供保护性免疫和预防疾病进展至关重要。T细胞群体分泌的细胞因子有助于激活巨噬细胞以杀死摄入的副结核分枝杆菌，并激活其他T细胞亚群以控制感染。本文基于临床研究和小鼠模型研究，综述了目前关于副结核分枝杆菌感染中T细胞免疫反应的知识。
