Mombelli B, Gismondo M R
Clinical Microbiology Department. L. Sacco Teaching Hospital, University of Milan, Via G.B. Grassi, 74, 20157 Milan, Italy.
Int J Antimicrob Agents. 2000 Dec;16(4):531-6. doi: 10.1016/s0924-8579(00)00322-8.
Probiotics are defined as living organisms, beneficial to health when ingested. Different species of microorganisms such as lactic acid bacteria or yeasts have been proposed for human use. These microorganisms differ from each other and it is, therefore, unlikely that they will act in the same way. Probiotics could be used for several conditions such as diarrhoea, candidal vaginitis, urinary tract infections, immune disorders, lactose intolerance, hypercholesterolaemia and food allergy. The effects of probiotics in some of these conditions have been directly observed, in others it has been only suggested on the basis of in vitro studies and from experimental animal models. Controlled trials are needed to determine the scientific basis for their use, the correct formulation and ways of administration in different clinical situations.
益生菌被定义为摄入后对健康有益的活的生物体。已有人提出将不同种类的微生物,如乳酸菌或酵母用于人类。这些微生物彼此不同,因此它们不太可能以相同的方式发挥作用。益生菌可用于多种病症,如腹泻、念珠菌性阴道炎、尿路感染、免疫紊乱、乳糖不耐受、高胆固醇血症和食物过敏。在其中一些病症中,益生菌的作用已得到直接观察,而在其他病症中,其作用只是基于体外研究和实验动物模型提出的。需要进行对照试验来确定其使用的科学依据、正确配方以及在不同临床情况下的给药方式。