Kraus F, Haenig B, Kispert A
Max-Planck-Institut für Immunbiologie, Abt. Molekulare Embryologie, Stübeweg 51, 79108 Freiburg, Germany.
Mech Dev. 2001 Jan;100(1):83-6. doi: 10.1016/s0925-4773(00)00494-9.
T-box genes encode transcription factors that regulate a variety of developmental processes. In this report, we describe the cloning and expression analysis of the novel mouse T-box gene Tbx18. During development expression is most prominent in the proepicardial organ and in the epicardium of the heart. Other sites of expression include the cranial paraxial mesoderm, the presomitic mesoderm, the anterior somite half, the genital ridge, and the developing limb buds.
T-box基因编码调控多种发育过程的转录因子。在本报告中，我们描述了新型小鼠T-box基因Tbx18的克隆及表达分析。在发育过程中，其表达在心脏的心外膜原基和心外膜中最为显著。其他表达位点包括颅旁轴中胚层、体节前中胚层、体节前半部分、生殖嵴和发育中的肢芽。
