兔对全身麻醉的肾循环反应：使用放射性微球的研究

Renal circulatory responses to general anaesthesia in the rabbit: studies using radioactive microspheres.

Warren D J, Ledingham J G

Clin Sci Mol Med. 1975 Jan;48(1):61-6. doi: 10.1042/cs0480061.

Abstract

Total renal blood flow and its cortical distribution were measured by the radioactive microsphere technique in conscious rabbits and after anaethesia with pentobarbitone, chloralose-urethane or ether. 2. Pentobarbitone anaesthesia caused a fall of 26% in total renal blood flow, of 26% in superficial cortical flow, and of 24% in deep cortical flow. Sodium excretion rate fell by 33%. 3. Chloralose-urethane anaesthesia caused no change in total or regional renal blood flow, or in sodium excretion. 4. Ether anaesthesia caused an insignificant fall in total renal blood flow, but superficial cortical flow fell by 13% and deep cortical flow rose by 21%. Urinary sodium excretion fell by 65%. 5. Possible mechanisms for these changes in response to anaesthesia are discussed. 6. The effects of anaesthetic agents may influence the interpretation of published work on control mechanisms in the renal circulation.

摘要

采用放射性微球技术，在清醒兔以及戊巴比妥、氯醛糖 - 乌拉坦或乙醚麻醉后的兔身上，测量了肾总血流量及其皮质分布。2. 戊巴比妥麻醉使肾总血流量下降26%，浅表皮质血流量下降26%，深部皮质血流量下降24%。钠排泄率下降33%。3. 氯醛糖 - 乌拉坦麻醉对肾总血流量或局部血流量以及钠排泄均无影响。4. 乙醚麻醉使肾总血流量有不显著下降，但浅表皮质血流量下降13%，深部皮质血流量上升21%。尿钠排泄下降65%。5. 讨论了这些麻醉反应变化的可能机制。6. 麻醉剂的作用可能会影响已发表的关于肾循环控制机制研究工作的解释。