肺炎链球菌中导致对16元大环内酯类和链阳菌素耐药的23S rRNA突变。
Mutation in 23S rRNA responsible for resistance to 16-membered macrolides and streptogramins in Streptococcus pneumoniae.
作者信息
Depardieu F, Courvalin P
机构信息
Unité des Agents Antibactériens, Institut Pasteur, 75724 Paris Cedex 15, France.
出版信息
Antimicrob Agents Chemother. 2001 Jan;45(1):319-23. doi: 10.1128/AAC.45.1.319-323.2001.
Abstract
Streptococcus pneumoniae clinical isolate BM4455 was resistant to 16-membered macrolides and to streptogramins. This unusual resistance phenotype was due to an A(2062)C (Escherichia coli numbering) mutation in domain V of the four copies of 23S rRNA.
摘要
肺炎链球菌临床分离株BM4455对16元大环内酯类抗生素和链阳菌素耐药。这种不寻常的耐药表型是由于23S rRNA四个拷贝的结构域V中发生了A(2062)C（大肠杆菌编号）突变。
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