Reinert Ralf René, Wild Angela, Appelbaum Peter, Lütticken Rudolf, Cil Murat Yücel, Al-Lahham Adnan
Institute of Medical Microbiology, National Reference Center for Streptococci, Aachen, Germany.
Antimicrob Agents Chemother. 2003 Jul;47(7):2319-22. doi: 10.1128/AAC.47.7.2319-2322.2003.
Among a collection of 4281 pneumococcal isolates, 7 strains isolated in Germany had an unusual macrolide resistance phenotype. The isolates were found to have multiple mutations in the 23S rRNA and alterations in the L4 ribosomal protein. One strain had an amino acid alteration in the L22 ribosomal protein.
在4281株肺炎球菌分离株中,德国分离出的7株具有不寻常的大环内酯耐药表型。这些分离株在23S rRNA中存在多个突变,并且L4核糖体蛋白发生改变。其中一株在L22核糖体蛋白中存在氨基酸改变。