Mahmood Nailah, Nawaz Rukhsana, Kadir Hidaya Abdul, Al Mughairbi Fadwa
Department of Cognitive Sciences, College of Humanities and Social Science, United Arab Emirates University, Al Ain, UAE.
Department of Biology, College of Science, United Arab Emirates University, Al Ain, UAE.
Oman Med J. 2021 Jul 31;36(4):e293. doi: 10.5001/omj.2021.89. eCollection 2021 Jul.
We sought to explore the expression of genes associated with depressive disorder in patients with depression compared to control patients. A large body of research in the area of genetics has shown familial aggregation for depressive disorders. The purpose of this study was to identify genetic risk factors in developing depression, particularly among the population residing in the UAE.
We investigated five associated genes (, , , , ) previously linked to depression and anxiety in other populations. The study was carried out in Al Ain, although participants were from different nationalities. Blood samples were collected over a period of seven months, and lab work was carried out over a period of two months from September 1, 2018 to May 30, 2019. We screened the prevalence of the , , , , and in 29 patients with depressive disorder and 30 controls using the quantitative real-time polymerase chain reaction method.
The expression of the gene, studied for the first time in the UAE population. The independent -test was used to check the significance of difference between the expression levels of target genes where the control was set at a reference level of 1.0. gene is lower among the depressed group which showed mean difference: 0.4 and -value: 0.02, indicating a strong association with depression. No significant difference was found in the genes' expression of with -value 0.150, -value 0.070, -value 0.750, and -value 0.100 in two groups in comparison with ( < 0.050).
These results open several possibilities for further research to study the role of this gene as a protective factor against developing depression.
我们试图探究抑郁症患者与对照患者相比，与抑郁症相关基因的表达情况。遗传学领域的大量研究表明抑郁症存在家族聚集性。本研究的目的是确定患抑郁症的遗传风险因素，特别是在阿联酋居住的人群中。
我们调查了先前在其他人群中与抑郁症和焦虑症相关的五个基因（、、、、）。该研究在艾因进行，尽管参与者来自不同国籍。在2018年9月1日至2019年5月30日的七个月时间内采集血样，并在两个月时间内进行实验室检测。我们使用定量实时聚合酶链反应方法筛查了29例抑郁症患者和30例对照中、、、、的患病率。
基因的表达情况，这是首次在阿联酋人群中进行研究。使用独立检验来检查目标基因表达水平之间差异的显著性，将对照设定为参考水平1.0。抑郁症组中基因较低，平均差异为0.4，值为0.02，表明与抑郁症有很强的关联。与相比，两组中基因、、、的表达无显著差异，值分别为0.150、0.070、0.750和0.100（<0.050）。
这些结果为进一步研究该基因作为预防抑郁症的保护因素的作用开辟了多种可能性。
