O'Leary G, Weiss R D
Harvard Medical School, Alcohol and Drug Abuse Treatment Program, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA.
Curr Psychiatry Rep. 2000 Dec;2(6):508-13. doi: 10.1007/s11920-000-0010-x.
This article reviews the history of pharmacologic trials for the treatment of cocaine dependence as well as current treatments under investigation. The rationale for use of agents such as dopaminergic agents, antidepressants, and anticonvulsants is discussed. Early clinical trials with pharmacologic agents have demonstrated both positive and negative results; the possible reasons for these mixed outcomes is also discussed. Recent studies focusing on disulfiram, dopamine-selective antagonists, citicoline, aspirin, and a cocaine-specific vaccine are presented to highlight innovative and potentially effective treatments for individuals with cocaine dependence.
本文回顾了治疗可卡因依赖的药理学试验历史以及正在研究的当前治疗方法。讨论了使用多巴胺能药物、抗抑郁药和抗惊厥药等药物的基本原理。早期使用药物的临床试验已显示出阳性和阴性结果；还讨论了这些混合结果的可能原因。介绍了近期针对双硫仑、多巴胺选择性拮抗剂、胞磷胆碱、阿司匹林和一种可卡因特异性疫苗的研究，以突出针对可卡因依赖个体的创新且可能有效的治疗方法。
