抗中性粒细胞胞浆抗体的临床价值

Clinical value of antineutrophil cytoplasmic antibodies.

作者信息

Rus V, Handwerger B S

机构信息

Division of Rheumatology and Clinical Immunology, University of Maryland Medical School, 10 South Pine Street, 8-34 MSTF, Baltimore, MD 21201-1192, USA.

出版信息

Curr Rheumatol Rep. 2000 Oct;2(5):383-9. doi: 10.1007/s11926-000-0037-3.

DOI:10.1007/s11926-000-0037-3

PMID:11123087

Abstract

This article presents a brief review of the clinical value of antineutrophil cytoplasmic antibodies (ANCA) in the diagnosis and management of patients with various forms of vasculitis. ANCA assay methodology and testing recommendations are reviewed. The patterns of reactivity of ANCA observed by indirect immunofluorescence, the antigens recognized by ANCA, and the sensitivity, specificity, and positive predictive value of ANCA for diagnosis of different vasculitides are described. In addition, the spectrum of drugs and nonvasculitic diseases that are associated with ANCA and need to be differentiated from true ANCA-positive vasculitides are reviewed. When properly utilized and cautiously interpreted, ANCA are a useful, noninvasive diagnostic tool in the differential diagnosis of vasculitis.

摘要

本文简要综述了抗中性粒细胞胞浆抗体（ANCA）在各种类型血管炎患者诊断和管理中的临床价值。文中回顾了ANCA检测方法及检测建议。描述了通过间接免疫荧光观察到的ANCA反应模式、ANCA识别的抗原，以及ANCA对不同血管炎诊断的敏感性、特异性和阳性预测值。此外，还综述了与ANCA相关且需要与真正ANCA阳性血管炎相鉴别的药物和非血管炎性疾病谱。当合理应用并谨慎解读时，ANCA是血管炎鉴别诊断中一种有用的非侵入性诊断工具。