Brotherton T W, Chui D H, Gauldie J, Patterson M
Proc Natl Acad Sci U S A. 1979 Jun;76(6):2853-7. doi: 10.1073/pnas.76.6.2853.
Pure populations of large, nucleated erythrocytes derived from yolk sac blood islands were obtained during normal fetal mouse development. Embryonic hemoglobins were present in these cells early in gestation. Later in gestation, an increasing amount of adults hemoglobin was also synthesized and accumulated in this population of primitive nucleated erythrocytes, as demonstrated by both biochemical and immunocytochemical techniques.
在正常小鼠胚胎发育过程中，从卵黄囊血岛获得了大量有核红细胞的纯群体。胚胎血红蛋白在妊娠早期就存在于这些细胞中。在妊娠后期，通过生化和免疫细胞化学技术均证实，在这群原始有核红细胞中也合成并积累了越来越多的成人血红蛋白。
