Brandsborg O, Brandsborg M, Christensen N J
Gastroenterology. 1975 Mar;68(3):455-60.
Serum gastrin, plasma adrenaline, and blood glucose concentration were measured in 12 patients during insulin-induced hypoglycemia. Six patients had a duodenal ulcer, and 6 patients, 2 to 3 months earlier, had undergone a selective gastric vagotomy due to a duodenal ulcer. The lowest blood glucose concentration was obtained 30 min after the injection of insulin. The rise in plasma adrenaline showed a significant correlation with the degree of hypoglycemia attained. Serum gastrin was approximately doubled in both groups of subjects during the test. There was a strong correlation between rise in serum gastrin expressed in percentage of the basal value and the plasma adrenaline during hypoglycemia. In other experiments, adrenaline was infused intravenously in normal subjects in amounts (6 mug per min for 20 min) resulting in plasma concentrations comparable to those seen during the infusion. It is concluded that adrenaline is a hitherto little recognized factor influencing the gastrin response to hypoglycemia.
在12名患者胰岛素诱发低血糖期间，测定了血清胃泌素、血浆肾上腺素和血糖浓度。6名患者患有十二指肠溃疡，另外6名患者在2至3个月前因十二指肠溃疡接受了选择性胃迷走神经切断术。注射胰岛素30分钟后获得最低血糖浓度。血浆肾上腺素的升高与达到的低血糖程度呈显著相关。在测试期间，两组受试者的血清胃泌素均增加了约一倍。低血糖期间，以基础值百分比表示的血清胃泌素升高与血浆肾上腺素之间存在强相关性。在其他实验中，向正常受试者静脉内输注肾上腺素（每分钟6微克，持续20分钟），导致血浆浓度与输注期间所见浓度相当。得出的结论是，肾上腺素是一个迄今鲜为人知的影响胃泌素对低血糖反应的因素。
