血浆去甲肾上腺素生理性升高对胃酸分泌和胃肠激素的影响。

Effects of physiological increases of plasma noradrenaline on gastric acid secretion and gastrointestinal hormones.

作者信息

Graffner H, Bloom S R, Farnebo L O, Järhult J

出版信息

Dig Dis Sci. 1987 Jul;32(7):715-9. doi: 10.1007/BF01296137.

Abstract

It is not known if the increased plasma concentration of noradrenaline in patients with chronic duodenal ulcer disease is a pathogenetic factor or not. The aim of the present study was to investigate if physiologic changes of noradrenaline would evoke any alterations in gastric acid secretion or in the plasma concentration of some gastrointestinal hormones (gastrin, secretin, PP, PYY, and GIP) known to affect gastric physiology. The results show that basal plasma noradrenaline concentration was 1.8 nM and after infusion with noradrenaline at 0.04 or 0.2 nmol/kg/min plasma levels of 2.5 and 4.4 nM were obtained. No appreciable changes could be found in basal or pentagastrin stimulated acid secretion or in any of the gastrointestinal peptides studied. If the elevated plasma noradrenaline concentration observed in duodenal ulcer patients is a pathogenetic factor; it is probable that it interferes with other variables such as blood flow, bicarbonate secretion, or prostaglandin synthesis.

摘要

目前尚不清楚慢性十二指肠溃疡病患者血浆去甲肾上腺素浓度升高是否为致病因素。本研究的目的是调查去甲肾上腺素的生理变化是否会引起胃酸分泌或一些已知影响胃生理的胃肠激素（胃泌素、促胰液素、胰多肽、肽YY和葡萄糖依赖性促胰岛素多肽）血浆浓度的任何改变。结果显示，基础血浆去甲肾上腺素浓度为1.8 nM，以0.04或0.2 nmol/kg/min的速率输注去甲肾上腺素后，血浆水平分别达到2.5和4.4 nM。在基础或五肽胃泌素刺激的胃酸分泌或所研究的任何胃肠肽中均未发现明显变化。如果在十二指肠溃疡患者中观察到的血浆去甲肾上腺素浓度升高是一个致病因素，那么它很可能会干扰其他变量，如血流、碳酸氢盐分泌或前列腺素合成。