Suppr超能文献

小鼠肿瘤引起的免疫抑制类似于抗原竞争。

Immunosuppression by a mouse tumor resembles antigenic competition.

作者信息

Cocito C G, Michot B, Radovich J, Talmage D W

出版信息

Proc Natl Acad Sci U S A. 1979 Jun;76(6):2895-7. doi: 10.1073/pnas.76.6.2895.

DOI:10.1073/pnas.76.6.2895
PMID:111246
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC383716/
Abstract

The intraperitoneal injection of gamma-radiated, UV-radiated, or unradiated P-815 tumor cells into syngeneic or allogeneic mice suppressed the immune response to a subsequent intraperitoneal injection of sheep erythrocytes in a manner similar to the suppression caused by the injection of manner similar to the suppression caused by the injection of horse erythrocytes and termed antigenic competition. In both cases, the greatest suppression occurred when the sheep erythrocytes were injected at the same site (intraperitoneal) as the tumor or antigen several days after the tumor or antigen and in a dose of 10(8) erythrocytes or less.

摘要

将经γ射线辐射、紫外线辐射或未经辐射的P - 815肿瘤细胞腹腔注射到同基因或异基因小鼠体内，会抑制对随后腹腔注射绵羊红细胞的免疫反应，其抑制方式类似于注射马红细胞所引起的抑制，这种现象被称为抗原竞争。在这两种情况下，当在肿瘤或抗原注射后几天，于与肿瘤或抗原相同的部位（腹腔）以10⁸个或更少的红细胞剂量注射绵羊红细胞时，抑制作用最为明显。

相似文献

1
Immunosuppression by a mouse tumor resembles antigenic competition.小鼠肿瘤引起的免疫抑制类似于抗原竞争。
Proc Natl Acad Sci U S A. 1979 Jun;76(6):2895-7. doi: 10.1073/pnas.76.6.2895.
2
Tumor-induced immunosuppression.肿瘤诱导的免疫抑制。
Am J Pathol. 1978 Nov;93(2):499-514.
3
Immunosuppression induced in vitro by mastocytoma tumor cells and cell-free extracts.肥大细胞瘤肿瘤细胞和无细胞提取物在体外诱导的免疫抑制。
J Immunol. 1975 Jun;114(6):1749-56.
4
Antigenic competition between heterologous erythrocytes in mice: interference with competition-inducing effect of sheep erythrocytes by inclusion of non-competing antigen.小鼠体内异源红细胞之间的抗原竞争：通过加入非竞争性抗原对绵羊红细胞竞争诱导效应的干扰
J Immunol. 1975 Jul;115(1):85-90.
5
Immunoglobulin receptors on mouse mast cells. II. Mast cells of different strains and mastocytomas.小鼠肥大细胞上的免疫球蛋白受体。II. 不同品系的肥大细胞和肥大细胞瘤
J Immunol. 1971 Dec;107(6):1795-7.
6
Subversion of immune system by tumor cells and role of prostaglandins.肿瘤细胞对免疫系统的颠覆及前列腺素的作用
Proc Natl Acad Sci U S A. 1975 May;72(5):1848-51. doi: 10.1073/pnas.72.5.1848.
7
Antigenic competition between horse and sheep red blood cells as a hormone-dependent phenomenon.马和绵羊红细胞之间的抗原竞争作为一种激素依赖性现象。
Clin Exp Immunol. 1979 Jul;37(1):106-13.
8
Antigenic competition between heterologous erythrocytes in mice. Immunological and histological studies exploring mechanisms of the antigenic competition.小鼠体内异源红细胞之间的抗原竞争。探索抗原竞争机制的免疫学和组织学研究。
Immunology. 1977 May;32(5):755-66.
9
Restoration of in vitro immune responsiveness of mastocytoma-suppressed splenocytes by activated T cells.活化T细胞对肥大细胞瘤抑制的脾细胞体外免疫反应性的恢复
J Immunol. 1975 Aug;115(2):382-6.
10
Humoral mediator of antigenic competition demonstrated in vivo.体内证实的抗原竞争体液介质。
Int Arch Allergy Appl Immunol. 1979;59(3):349-56. doi: 10.1159/000232280.

本文引用的文献

1
Antigenic competition: cellular or humoral.抗原竞争：细胞性或体液性。
Science. 1967 Oct 27;158(3800):512-4. doi: 10.1126/science.158.3800.512.
2
Antibody-producing capacity in human cancer.人类癌症中的抗体产生能力。
Br J Cancer. 1970 Sep;24(3):454-63. doi: 10.1038/bjc.1970.54.
3
Inhibition of phytohemagglutinin-induced in vitro lymphocyte transformation by serum from patients with carcinoma.癌患者血清对植物血凝素诱导的体外淋巴细胞转化的抑制作用。
J Natl Cancer Inst. 1971 Jun;46(6):1291-7.
4
Lymphocyte sensitization in advanced malignant disease: a study of serum lymphocyte depressive factor.晚期恶性疾病中的淋巴细胞致敏作用：血清淋巴细胞抑制因子的研究
Br J Cancer. 1972 Jun;26(3):164-73. doi: 10.1038/bjc.1972.23.
5
Plaque forming cells: methodology and theory.噬斑形成细胞：方法与理论
Transplant Rev. 1974;18:130-91. doi: 10.1111/j.1600-065x.1974.tb01588.x.
6
Immunosuppressive and immunostimulatory factors produced by malignant cells in vitro.恶性细胞在体外产生的免疫抑制和免疫刺激因子。
Int J Cancer. 1974 Apr 15;13(4):530-42. doi: 10.1002/ijc.2910130413.
7
Depressed cell-mediated immunity in patients with primary intracranial tumors. Characterization of a humoral immunosuppressive factor.原发性颅内肿瘤患者细胞介导免疫功能低下。一种体液免疫抑制因子的特性。
J Exp Med. 1972 Dec 1;136(6):1631-47. doi: 10.1084/jem.136.6.1631.
8
Immunodeficiency and cancer.免疫缺陷与癌症。
Adv Cancer Res. 1973;18:211-30. doi: 10.1016/s0065-230x(08)60753-8.
9
Activation of cytotoxic T cells by nonstimulating tumor cells and spleen cell factor(s).非刺激型肿瘤细胞和脾细胞因子激活细胞毒性T细胞。
Proc Natl Acad Sci U S A. 1977 Oct;74(10):4610-4. doi: 10.1073/pnas.74.10.4610.
10
Immunosuppression by spleen cells from Moloney leukemia. Comparison of the suppressive effect on antibody response and on mitogen-induced response.莫洛尼白血病脾细胞所致的免疫抑制。对抗体应答和有丝分裂原诱导应答的抑制作用比较。
J Immunol. 1975 Oct;115(4):943-9.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验