Cocito C G, Michot B, Radovich J, Talmage D W
Proc Natl Acad Sci U S A. 1979 Jun;76(6):2895-7. doi: 10.1073/pnas.76.6.2895.
The intraperitoneal injection of gamma-radiated, UV-radiated, or unradiated P-815 tumor cells into syngeneic or allogeneic mice suppressed the immune response to a subsequent intraperitoneal injection of sheep erythrocytes in a manner similar to the suppression caused by the injection of manner similar to the suppression caused by the injection of horse erythrocytes and termed antigenic competition. In both cases, the greatest suppression occurred when the sheep erythrocytes were injected at the same site (intraperitoneal) as the tumor or antigen several days after the tumor or antigen and in a dose of 10(8) erythrocytes or less.
将经γ射线辐射、紫外线辐射或未经辐射的P - 815肿瘤细胞腹腔注射到同基因或异基因小鼠体内,会抑制对随后腹腔注射绵羊红细胞的免疫反应,其抑制方式类似于注射马红细胞所引起的抑制,这种现象被称为抗原竞争。在这两种情况下,当在肿瘤或抗原注射后几天,于与肿瘤或抗原相同的部位(腹腔)以10⁸个或更少的红细胞剂量注射绵羊红细胞时,抑制作用最为明显。