Wheeler D L, Church D M, Lash A E, Leipe D D, Madden T L, Pontius J U, Schuler G D, Schriml L M, Tatusova T A, Wagner L, Rapp B A
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.
Nucleic Acids Res. 2001 Jan 1;29(1):11-6. doi: 10.1093/nar/29.1.11.
In addition to maintaining the GenBank nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides data analysis and retrieval resources that operate on the data in GenBank and a variety of other biological data made available through NCBI's Web site. NCBI data retrieval resources include Entrez, PubMed, LocusLink and the Taxonomy Browser. Data analysis resources include BLAST, Electronic PCR, OrfFinder, RefSeq, UniGene, HomoloGene, Database of Single Nucleotide Polymorphisms (dbSNP), Human Genome Sequencing, Human MapViewer, GeneMap'99, Human-Mouse Homology Map, Cancer Chromosome Aberration Project (CCAP), Entrez Genomes, Clusters of Orthologous Groups (COGs) database, Retroviral Genotyping Tools, Cancer Genome Anatomy Project (CGAP), SAGEmap, Gene Expression Omnibus (GEO), Online Mendelian Inheri-tance in Man (OMIM), the Molecular Modeling Database (MMDB) and the Conserved Domain Database (CDD). Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets. All of the resources can be accessed through the NCBI home page at: http://www.ncbi.nlm.nih. gov.
除维护GenBank核酸序列数据库外,美国国立生物技术信息中心(NCBI)还提供数据分析和检索资源,这些资源可处理GenBank中的数据以及通过NCBI网站提供的各种其他生物数据。NCBI的数据检索资源包括Entrez、PubMed、LocusLink和分类浏览器。数据分析资源包括BLAST、电子PCR、开放阅读框查找器(OrfFinder)、参考序列(RefSeq)、单基因簇(UniGene)、同源基因(HomoloGene)、单核苷酸多态性数据库(dbSNP)、人类基因组测序、人类图谱浏览器、基因图谱99、人类-小鼠同源性图谱、癌症染色体畸变项目(CCAP)、Entrez基因组、直系同源簇(COG)数据库、逆转录病毒基因分型工具、癌症基因组解剖项目(CGAP)、SAGEmap、基因表达综合数据库(GEO)、《人类孟德尔遗传在线》(OMIM)、分子建模数据库(MMDB)和保守结构域数据库(CDD)。许多网络应用程序都增强了BLAST程序的定制实现,这些实现经过优化可搜索特定的数据集。所有资源均可通过NCBI主页访问:http://www.ncbi.nlm.nih.gov 。