血管紧张素（I、II和III）、缓激肽及花生四烯酸对肾髓质前列腺素E体外生成的影响
Influence of angiotensins (I, II, & III), bradykinin and arachidonic acid on renomedullary PGE production in vitro.
作者信息
Anees M, Sweet P, Tan S Y, Mulrow P J
出版信息
Prostaglandins. 1979 Apr;17(4):515-23. doi: 10.1016/0090-6980(79)90004-2.
Renomedullary tissue from rabbit or rat was incubated with angiotensin I, II, III, arachidonic acid, bradykinin, indomethacin and meclofenamate to study their effect on PGE2 production. Arachidonic acid and bradykinin enhanced PGE2 production significantly. Indomethacin and meclofenamate inhibited PGE2 production by more than 70%. Angiotensin I, II and III did not influence PGE2 production. These results suggest that bradykinin and arachidonic acid stimulate PGE2 production by a direct cellular action whereas the angiotensins do not.
将来自兔子或大鼠的肾髓质组织与血管紧张素I、II、III、花生四烯酸、缓激肽、吲哚美辛和甲氯芬那酸一起孵育，以研究它们对前列腺素E2（PGE2）产生的影响。花生四烯酸和缓激肽显著增强了PGE2的产生。吲哚美辛和甲氯芬那酸抑制PGE2的产生超过70%。血管紧张素I、II和III对PGE2的产生没有影响。这些结果表明，缓激肽和花生四烯酸通过直接的细胞作用刺激PGE2的产生，而血管紧张素则不然。
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