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体外冲击波碎石术治疗尿路结石

Lithotripsy in the treatment of urinary lithiasis.

作者信息

Tombolini P, Ruoppolo M, Bellorofonte C, Zaatar C, Follini M

机构信息

Division of Urology, San Carlo Borromeo Hospital, Milan, Italy.

出版信息

J Nephrol. 2000 Nov-Dec;13 Suppl 3:S71-82.

Abstract

Based on an extensive review of the literature and on our own clinical experience, this article attempts to present clear guidelines for the management of various kidney stones, particularly regarding the extracorporeal shock waves lithotripsy (ESWL) treatment nowadays. Few technical developments have changed medicine more within a short period of time than ESWL. Fifteen years after the first clinical application, ESWL has gained world-wide acceptance as first choice therapy for most forms of urolithiasis. Ninety-eight per cent of stones can be successfully fragmented by the application of shock-waves, but the ability of the kidney and ureter to clear the resulting fragments is far more important in terms of successful treatment outcome. Increasing experience with new ultrasound-guided lithotriptors has shown that there are some advantages: cost reduction, permanent monitoring and lack of exposure to ionising radiations. ESWL is a safe procedure for the treatment of urolithiasis; nevertheless some problems remain. In ureteric stones, ureteroscopy (rigid or flexible device) allows a rate of stone-free patients better than ESWL. For treatment of large staghorn calculi combined approach of PCNL and ESWL is preferred. For stones located at lower calyx, the stone-free rate in patients treated by ESWL fell to 50%, when unfavourable anatomy is present. The potential long-term renal damage, associated with ESWL in children, have delayed the acceptance of shock-waves into paediatric practice. Recent reports suggest that the renal damage, including the potential risk of hypertension induced by ESWL, is mild and transient. A subgroup of patients (e.g. solitary kidney, impaired renal function, children) required further attention. The fate of residual fragments is unclear. In some cases residual lithiasis tend to result in regrowth and further progression, although ESWL itself does not increase the recurrence rate of urolithiasis. Nevertheless follow-up of stone patients after ESWL is mandatory and the ultimate goal of treating stones by whatever means is to get the patient stone-free and prevent recurrence.

摘要

基于对文献的广泛综述以及我们自己的临床经验,本文试图为各种肾结石的治疗提供明确的指导方针,特别是关于当今的体外冲击波碎石术(ESWL)治疗。在短时间内,很少有技术发展能比ESWL对医学产生更大的改变。首次临床应用15年后,ESWL已作为大多数形式尿路结石的首选治疗方法在全球范围内得到认可。通过应用冲击波,98%的结石能够成功破碎,但就治疗成功结果而言,肾脏和输尿管清除产生的碎片的能力更为重要。对新型超声引导碎石器的经验不断增加表明其具有一些优点:成本降低、持续监测以及无电离辐射暴露。ESWL是治疗尿路结石的一种安全方法;然而,仍然存在一些问题。对于输尿管结石,输尿管镜检查(硬性或软性器械)使结石清除率优于ESWL。对于大鹿角形结石的治疗,首选经皮肾镜取石术(PCNL)和ESWL的联合方法。对于位于下肾盏的结石,当存在不利解剖结构时,接受ESWL治疗的患者结石清除率降至50%。与儿童ESWL相关的潜在长期肾脏损害,延缓了冲击波在儿科实践中的应用。最近的报告表明,包括ESWL诱发高血压的潜在风险在内的肾脏损害是轻微且短暂的。一部分患者(如孤立肾、肾功能受损、儿童)需要进一步关注。残留碎片的转归尚不清楚。在某些情况下,尽管ESWL本身不会增加尿路结石的复发率,但残留结石往往会导致再生长和进一步进展。然而,ESWL治疗后对结石患者进行随访是必不可少的,并且无论采用何种方法治疗结石的最终目标都是使患者无结石并预防复发。

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