来自黑指纹海兔（Aplysia kurodai）卵的一种新型三膦酰八糖神经酰胺的表征。
Characterization of a novel triphosphonooctaosylceramide from the eggs of the sea hare, Aplysia kurodai.
作者信息
Araki S, Yamada S, Abe S, Waki H, Kon K, Itonori S, Sugita M, Ando S
机构信息
Department of Cellular Neurobiology, Brain Research Institute, Niigata University, Asahimachi-Niigata, Niigata 951-8585, Japan.
出版信息
J Biochem. 2001 Jan;129(1):93-100. doi: 10.1093/oxfordjournals.jbchem.a002841.
We have reported the existence of a triphosphonoglycosphingolipid, EGL-I, in the eggs of a sea gastropod, Aplysia kurodai [Yamada, S., Araki, S., Abe, S., Kon, K., Ando, S., and Satake, M. (1995) J. Biochem. 117, 794-799]. We have now isolated a novel glycosphingolipid, named EGL-II, from the eggs of Aplysia. By component analysis, sugar analysis, permethylation studies, fast atom bombardment-mass spectrometry, secondary ion mass spectrometry, and proton magnetic resonance spectrometry, its structure was revealed to be as follows: Galalpha1-->3(GlcNAcalpha1-->2)Galalpha1-->3(3-O-MeGalalpha1-->2)Galalpha1-->36'-O-(2-aminoethylphosphonyl)Galalpha1-->2Galbeta1-->4(2-aminoethylphosphonyl-->6)Glcbeta1-->1ceramide. The major aliphatic components of the ceramide are palmitic acid, stearic acid, and anteisononadeca-4-sphingenine.
我们曾报道过海蛞蝓黑指纹海兔（Aplysia kurodai）的卵中存在一种三膦糖鞘脂，EGL-I [山田，S.，荒木，S.，阿部，S.，孔，K.，安藤，S.，和笹岳，M.（1995年）《生物化学杂志》117卷，794 - 799页]。我们现在从黑指纹海兔的卵中分离出了一种新型糖鞘脂，命名为EGL-II。通过成分分析、糖类分析、全甲基化研究、快原子轰击质谱、二次离子质谱和质子磁共振光谱分析，其结构如下：Galα1→3(GlcNAcα1→2)Galα1→3(3 - O - MeGalα1→2)Galα1→3[6'-O-(2 - 氨乙基膦酰基)Galα1→2](2 - 氨乙基膦酰基→6)Galβ1→4(2 - 氨乙基膦酰基→6)Glcβ1→1神经酰胺。神经酰胺的主要脂肪族成分是棕榈酸、硬脂酸和反异十九碳 - 4 - 鞘氨醇。
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