Parker S J, Watkins P E
Biomedical Sciences, Defence Evaluation and Research Agency, Porton Down, Salisbury SP4 OJQ, UK.
Br J Surg. 2001 Jan;88(1):22-30. doi: 10.1046/j.1365-2168.2001.01632.x.
The mortality rate from sepsis has improved little over the past two decades. One reason for this has been the use of flawed or inappropriate experimental models in preclinical sepsis studies.
A literature review of animal models of sepsis was performed following a Medline search based on the following medical subject headings: disease models, endotoxin, inflammation, peritonitis and sepsis. Additional references were identified from the papers identified in the search.
Many animal models of sepsis have been described but none has proved to be superior. Extrapolation of results from endotoxicosis or bacterial infusion models should be regarded with caution. Peritonitis models should be accepted as the 'gold standard' but the use of appropriate virulent bacterial species needs to be ensured. A standardized panel of animal models for the preclinical assessment of immunomodulatory agents should be established, including at least one immuno- suppressed model to simulate the immunocompromised patient with sepsis. A uniform and valid definition of sepsis applicable to both small and large animal species is required.
在过去二十年中，脓毒症的死亡率几乎没有改善。造成这种情况的一个原因是在临床前脓毒症研究中使用了有缺陷或不恰当的实验模型。
基于以下医学主题词在Medline上进行搜索后，对脓毒症动物模型进行了文献综述：疾病模型、内毒素、炎症、腹膜炎和脓毒症。从搜索中确定的论文中识别出其他参考文献。
已经描述了许多脓毒症动物模型，但没有一个被证明是优越的。对内毒素血症或细菌注入模型的结果推断应谨慎对待。腹膜炎模型应被视为“金标准”，但需要确保使用适当的有毒细菌种类。应建立一个用于免疫调节药物临床前评估的标准化动物模型组，包括至少一个免疫抑制模型，以模拟脓毒症免疫功能低下的患者。需要一个适用于小型和大型动物物种的统一且有效的脓毒症定义。
