Henin A, Savage C R, Rauch S L, Deckersbach T, Wilhelm S, Baer L, Otto M W, Jenike M A
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129-2060, USA.
Am J Psychiatry. 2001 Jan;158(1):137-9. doi: 10.1176/appi.ajp.158.1.137.
Age at onset is a potentially important marker for neurobiological features of obsessive-compulsive disorder (OCD). This study examined the relationship between age at symptom onset and memory impairment in adults with OCD.
The authors used the Rey-Osterrieth Complex Figure Test and the California Verbal Learning Test to compare memory functioning of 37 adult OCD patients with self-reported childhood onset of symptoms (onset at less than 18 years of age) with that of 31 patients with adult-onset symptoms.
No differences were found between the two groups on any of the verbal and nonverbal memory measures.
Self-reported age at symptom onset is not associated with memory performance in adult patients with OCD according to tests previously found to be sensitive to frontal-striatal system dysfunction and impairment in OCD. Such dysfunction appears to be a consistent feature of OCD in adults, regardless of age at initial symptom onset.
发病年龄是强迫症（OCD）神经生物学特征的一个潜在重要指标。本研究探讨了成年强迫症患者症状发作年龄与记忆损害之间的关系。
作者使用雷-奥斯特里思复杂图形测验和加利福尼亚言语学习测验，比较了37名自报童年期症状发作（18岁之前发病）的成年强迫症患者与31名成年期症状发作患者的记忆功能。
两组在任何言语和非言语记忆测量指标上均未发现差异。
根据先前发现对强迫症中额叶-纹状体系统功能障碍和损害敏感的测试，自报症状发作年龄与成年强迫症患者的记忆表现无关。这种功能障碍似乎是成年强迫症患者的一个一致特征，无论初始症状发作年龄如何。
