Gray S G, Ekström T J
Laboratory for Molecular Development and Tumor Biology, Centre for Molecular Medicine (CMM), Stockholm, S-171 76, Sweden.
Exp Cell Res. 2001 Jan 15;262(2):75-83. doi: 10.1006/excr.2000.5080.
Since the identification of the first histone deacetylase (Taunton et al., Science 272, 408-411), several new members have been isolated. They can loosely be separated into entities on the basis of their similarity to various yeast histone deacetylases. The first class is represented by its closeness to the yeast Rpd3-like proteins, and the second most recently discovered class has similarities to yeast Hda1-like proteins. However, due to the fact that several different research groups isolated the Hda1-like histone deacetylases independently, there have been various different nomenclatures used to describe the various members, which can lead to confusion in the interpretation of this family's functions and interactions. With the discovery of another novel murine histone deacetylase, homologous to yeast Sir2, the number of members of this family is set to increase, as 7 human homologues of this gene have been isolated. In the light of these recent discoveries, we have examined the literature data and conducted a database analysis of the isolated histone deacetylases and potential candidates. The results obtained suggest that the number of histone deacetylases within the human genome may be as high as 17 and are discussed in relation to their homology to the yeast histone deacetylases.
自首个组蛋白去乙酰化酶被鉴定出来（汤顿等人，《科学》272卷，408 - 411页）以来，又分离出了几个新成员。根据它们与各种酵母组蛋白去乙酰化酶的相似性，可大致将它们分为不同类别。第一类以其与酵母Rpd3样蛋白的相似性为代表，第二类是最近发现的，与酵母Hda1样蛋白相似。然而，由于几个不同的研究小组独立分离出了Hda1样组蛋白去乙酰化酶，因此用于描述各个成员的命名法各不相同，这可能会导致在解释该家族的功能和相互作用时产生混淆。随着另一种与酵母Sir2同源的新型小鼠组蛋白去乙酰化酶的发现，该家族的成员数量将会增加，因为已分离出该基因的7个人类同源物。鉴于这些最新发现，我们查阅了文献数据，并对已分离的组蛋白去乙酰化酶和潜在候选物进行了数据库分析。所得结果表明，人类基因组中的组蛋白去乙酰化酶数量可能高达17种，并就它们与酵母组蛋白去乙酰化酶的同源性进行了讨论。
