State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Department of Basic and Diagnostic Sciences, College of Veterinary Science, Mekelle University, Mekelle, Tigray, Ethiopia.
Front Immunol. 2023 Aug 11;14:1216548. doi: 10.3389/fimmu.2023.1216548. eCollection 2023.
In the family of histone-deacetylases, histone deacetylase 6 (HDAC6) stands out. The cytoplasmic class IIb histone deacetylase (HDAC) family is essential for many cellular functions. It plays a crucial and debatable regulatory role in innate antiviral immunity. This review summarises the current state of our understanding of HDAC6's structure and function in light of the three mechanisms by which it controls DNA and RNA virus infection: cytoskeleton regulation, host innate immune response, and autophagy degradation of host or viral proteins. In addition, we summed up how HDAC6 inhibitors are used to treat a wide range of diseases, and how its upstream signaling plays a role in the antiviral mechanism. Together, the findings of this review highlight HDAC6's importance as a new therapeutic target in antiviral immunity, innate immune response, and some diseases, all of which offer promising new avenues for the development of drugs targeting the immune response.
在组蛋白去乙酰化酶家族中，组蛋白去乙酰化酶 6（HDAC6）尤为突出。细胞质 IIb 类组蛋白去乙酰化酶（HDAC）家族对于许多细胞功能至关重要。它在先天抗病毒免疫中起着关键且有争议的调节作用。本综述总结了目前我们对 HDAC6 的结构和功能的理解，重点介绍了它控制 DNA 和 RNA 病毒感染的三种机制：细胞骨架调节、宿主固有免疫反应和宿主或病毒蛋白的自噬降解。此外，我们总结了 HDAC6 抑制剂如何用于治疗广泛的疾病，以及其上游信号如何在抗病毒机制中发挥作用。综上所述，本综述的研究结果强调了 HDAC6 作为抗病毒免疫、固有免疫反应和一些疾病的新治疗靶点的重要性，为靶向免疫反应的药物开发提供了有前途的新途径。
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