Wesnes K A, Ward T, McGinty A, Petrini O
Cognitive Drug Research Ltd, Reading, UK.
Psychopharmacology (Berl). 2000 Nov;152(4):353-61. doi: 10.1007/s002130000533.
The effects of capsules containing 60 mg of a standardised extract of Ginkgo biloba (GK501) and 100 mg of a standardised extract of Panax ginseng (G115) on various aspects of cognitive function were assessed in healthy middle-aged volunteers. A double blind, placebo controlled, 14 week, parallel group, repeated assessment, multi-centre trial of two dosing regimens, 160 mg b.i.d. and 320 mg o.d. was conducted. Two hundred and fifty-six healthy middle-aged volunteers successfully completed the study. On various study days (weeks 0, 4, 8, 12 and 14) the volunteers performed a selection of tests of attention and memory from the Cognitive Drug Research computerised cognitive assessment system prior to morning dosing and again, at 1, 3 and 6 h later. The volunteers also completed questionnaires about mood states, quality of life and sleep quality. The Ginkgo/ginseng combination was found significantly to improve an Index of Memory Quality, supporting a previous finding with the compound. This effect represented an average improvement of 7.5% and reflected improvements to a number of different aspects of memory, including working and long-term memory. This enhancement to memory was seen throughout the 12-week dosing period and also after a 2-week washout. This represents the first substantial demonstration of improvements to the memory of healthy middle-aged volunteers produced by a phytopharmaceutical.
在健康中年志愿者中评估了含有60毫克银杏叶标准化提取物（GK501）和100毫克人参标准化提取物（G115）的胶囊对认知功能各个方面的影响。进行了一项双盲、安慰剂对照、为期14周的平行组、重复评估、多中心试验，涉及两种给药方案，即每日两次，每次160毫克和每日一次，每次320毫克。256名健康中年志愿者成功完成了该研究。在不同的研究日（第0、4、8、12和14周），志愿者在早晨给药前以及给药后1、3和6小时，使用认知药物研究计算机化认知评估系统进行了一系列注意力和记忆力测试。志愿者还完成了关于情绪状态、生活质量和睡眠质量的问卷调查。发现银杏/人参组合能显著改善记忆质量指数，支持了之前对该化合物的研究结果。这种效果平均提高了7.5%，反映出记忆的多个不同方面都有所改善，包括工作记忆和长期记忆。在整个12周的给药期以及2周的洗脱期后都观察到了对记忆的增强作用。这是首次充分证明一种植物药对健康中年志愿者的记忆力有改善作用。
