Williams R, Suggs J, Creason J, Rodes C, Lawless P, Kwok R, Zweidinger R, Sheldon L
US Environmental Protection Agency, National Exposure Research Laboratory, Research Triangle Park, North Carolina 27711, USA.
J Expo Anal Environ Epidemiol. 2000 Nov-Dec;10(6 Pt 1):533-43. doi: 10.1038/sj.jea.7500108.
An integrated epidemiological-exposure panel study was conducted during the summer of 1998 which focused upon establishing relationships between potential human exposures to particulate matter (PM) and related co-pollutants with detectable health effects. The study design incorporated repeated individual 24-h integrated PM2.5 personal exposure monitoring. A total of 325 PM2.5 personal exposure samples were obtained during a 28-day study period using a subject pool of 21 elderly (65+ years of age) residents of an 18-story retirement facility near Baltimore, Maryland. Each sample represented a unique 24-h breathing zone measurement of PM2.5 mass concentration. PM2.5 and PM10 mass concentrations collected from the apartments of the subjects as well as residential and ambient sites were compared to individual and mean PM2.5 personal exposures. Daily PM2.5 personal exposure concentrations ranged from 2.4 to 47.8 microg/m3 with an overall individual study mean of 12.9 microg/m3. Mean PM2.5 personal exposures were determined to be highly correlated to those representing the central indoor (r=0.90) and ambient sites (r=0.89). Subjects reported spending an average of 92% of each day within the confines of the retirement center. Based upon measured and modeled exposures, a mean PM2.5 personal cloud of 3.1 microg/m3 was estimated. Data collected from these participants may be unique with respect to the general elderly population due to the communal lifestyle within the facility and reported low frequency of exposure to sources of PM.
1998年夏季开展了一项综合流行病学暴露小组研究,重点是确定人类潜在接触颗粒物(PM)及相关共污染物与可检测到的健康影响之间的关系。该研究设计纳入了重复的个体24小时PM2.5个人暴露监测。在为期28天的研究期间,利用马里兰州巴尔的摩附近一个18层退休设施中的21名老年(65岁及以上)居民作为受试者群体,共获得了325个PM2.5个人暴露样本。每个样本代表了一个独特的24小时呼吸带PM2.5质量浓度测量值。将从受试者公寓以及住宅和环境场所收集的PM2.5和PM10质量浓度与个体和平均PM2.5个人暴露进行比较。每日PM2.5个人暴露浓度范围为2.4至47.8微克/立方米,个体研究总体平均值为12.9微克/立方米。确定平均PM2.5个人暴露与代表室内中心(r=0.90)和环境场所(r=0.89)的暴露高度相关。受试者报告平均每天有92%的时间在退休中心范围内度过。根据测量和模拟的暴露情况,估计平均PM2.5个人云团为3.1微克/立方米。由于该设施内的集体生活方式以及报告的接触PM来源的频率较低,从这些参与者收集的数据可能在一般老年人群中具有独特性。