个人和环境水平的二氧化氮和颗粒物暴露对心血管功能的影响。
Impact of personal and ambient-level exposures to nitrogen dioxide and particulate matter on cardiovascular function.
机构信息
National Exposure Research Laboratory, U.S. Environmental Protection Agency (US EPA), Research Triangle Park, NC, USA.
出版信息
Int J Environ Health Res. 2012;22(1):71-91. doi: 10.1080/09603123.2011.588437. Epub 2011 Jun 28.
Abstract
This work explored the association between nitrogen dioxide (NO(2)) and PM(2.5) components with changes in cardiovascular function in an adult non-smoking cohort. The cohort consisted of 65 volunteers participating in the US EPA's Detroit Exposure and Aerosol Research Study (DEARS) and a University of Michigan cardiovascular sub-study. Systolic and diastolic blood pressure (SBP, DBP), heart rate (HR), brachial artery diameter (BAD), brachial artery flow-mediated dilatation (FMD) and nitroglycerin-mediated arterial dilatation (NMD) were collected by in-home examinations. A maximum of 336 daily environmental and health effect observations were obtained. Daily potassium air concentrations were associated with significant decreases in DBP (-0.0447 mmHg/ng/m(3) ± 0.0132, p = 0.0016, lag day 0) among participants compliant with the personal monitoring protocol. Personal NO(2) exposures resulted in significant changes in BAD (e.g., 0.0041 mm/ppb ± 0.0019, p = 0.0353, lag day 1) and FMD (0.0612 ± 0.0235, p = 0.0103, lag day 0) among other findings.
摘要
本研究旨在探讨在成年不吸烟人群中，二氧化氮（NO2）和 PM2.5 成分与心血管功能变化之间的关系。该队列由 65 名志愿者组成，他们参与了美国环保署的底特律暴露和气溶胶研究（DEARS）以及密歇根大学心血管子研究。在家中检查时，收集了收缩压和舒张压（SBP、DBP）、心率（HR）、肱动脉直径（BAD）、肱动脉血流介导的扩张（FMD）和硝酸甘油介导的动脉扩张（NMD）。共获得了 336 次每日环境和健康效应观察。在遵守个人监测方案的参与者中，空气中钾浓度与 DBP 显著降低相关（-0.0447 mmHg/ng/m3 ± 0.0132，p = 0.0016，滞后 0 天）。个人 NO2 暴露导致 BAD 发生显著变化（例如，0.0041 mm/ppb ± 0.0019，p = 0.0353，滞后 1 天），以及 FMD 显著变化（0.0612 ± 0.0235，p = 0.0103，滞后 0 天），这是其他研究结果。
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