Camargo P M, Lekovic V, Weinlaender M, Nedic M, Vasilic N, Wolinsky L E, Kenney E B
University of California, Los Angeles, School of Dentistry, 90095, USA.
J Clin Periodontol. 2000 Dec;27(12):889-96. doi: 10.1034/j.1600-051x.2000.027012889.x.
The purpose of this study was to evaluate the clinical effectiveness of a bovine porous bone mineral used in combination with a porcine derived collagen membrane as a barrier in promoting periodontal regeneration in intrabony defects in humans.
The study employed a split-mouth design. 22 paired intrabony defects were treated and surgically re-entered 6 months after treatment. Experimental sites were grafted with bovine porous bone mineral and received a collagen membrane for guided tissue regeneration. Control sites were treated with an open flap debridement.
Preoperative pocket depths, attachment levels and trans-operative bone measurements were similar for control and experimental sites. Post surgical measurements revealed a significantly greater reduction in pocket depth (differences of 1.89 +/- 0.31 mm on buccal 0.88 +/- 0.27 mm on lingual measurements) and more gain in clinical attachment (differences of 1.51 +/- 0.33 mm on buccal and 1.50 +/- 0.35 mm on lingual measurements) in experimental sites. Surgical reentry of the treated defects revealed a significantly greater amount of defect fill in favor of experimental sites (differences of 2.67 +/- 0.91 mm on buccal and 2.54 +/- 0.87 mm on lingual measurements).
The results of this study indicate that clinical resolution of intrabony defects can be achieved using a combination of bovine porous bone mineral and an absorbable, porcine derived collagen membrane when employing a technique based on the principles of guided tissue regeneration. The nature of the attachment between the newly regenerated tissue and the root surfaces needs to be evaluated histologically to confirm the presence of new attachment.
本研究旨在评估牛多孔骨矿物质与猪源胶原膜联合作为屏障在促进人类骨内缺损牙周再生中的临床效果。
本研究采用双侧对照设计。对22对骨内缺损进行治疗，并在治疗6个月后进行手术再探查。试验部位植入牛多孔骨矿物质并覆盖胶原膜以引导组织再生。对照部位采用开放性龈瓣清创术治疗。
对照部位和试验部位术前的牙周袋深度、附着水平和术中骨测量结果相似。术后测量显示，试验部位的牙周袋深度显著降低更多（颊侧测量差异为1.89±0.31mm，舌侧测量差异为0.88±0.27mm），临床附着增加更多（颊侧测量差异为1.51±0.33mm，舌侧测量差异为1.50±0.35mm）。对治疗后的缺损进行手术再探查显示，试验部位的缺损填充量显著更多（颊侧测量差异为2.67±0.91mm，舌侧测量差异为2.54±0.87mm）。
本研究结果表明，当采用基于引导组织再生原理的技术时，联合使用牛多孔骨矿物质和可吸收的猪源胶原膜可实现骨内缺损的临床修复。需要通过组织学评估新再生组织与牙根表面之间附着的性质，以确认新附着的存在。
