Lekovic V, Camargo P M, Weinlaender M, Nedic M, Aleksic Z, Kenney E B
University of California Los Angeles, School of Dentistry, 90095, USA.
J Periodontol. 2000 Jul;71(7):1110-6. doi: 10.1902/jop.2000.71.7.1110.
It has been shown that clinical improvement of intrabony periodontal defects can be achieved with the use of enamel matrix proteins (EMPs) or by grafting with bovine porous bone mineral (BPBM). There is no report on the potential synergistic effect of EMPs and BPBM in periodontal regenerative therapy. The purpose of this study was to compare the clinical effectiveness of EMPs used alone or in combination with BPBM in the treatment of periodontal intrabony defects in humans.
Twenty-one paired intrabony defects were surgically treated using a split-mouth design. Intrabony defects were treated either with enamel matrix proteins (EMP group) or with enamel matrix proteins combined with bovine porous bone mineral (EMP/BPBM group). Re-entry surgeries were performed at 6 months.
Preoperative probing depths, attachment levels, and transoperative bone measurements were similar for the EMP and EMP/BPBM groups. Postsurgical measurements taken at 6 months revealed a significantly greater reduction in probing depth in the EMP/BPBM group (3.43 +/- 1.32 mm on buccal sites and 3.36 +/- 1.35 mm on lingual sites) when compared to the EMP group (1.91 +/- 1.42 mm on buccal sites and 1.85 +/- 1.38 mm on lingual sites). The EMP/BPBM group also presented with significantly more attachment gain (3.13 +/- 1.41 mm on buccal sites and 3.11 +/- 1.39 mm on lingual sites) than the EMP group (1.72 +/- 1.33 mm on buccal sites and 1.75 +/- 1.37 mm on lingual sites). Surgical re-entry of the treated defects revealed a significantly greater amount of defect fill in favor of the EMP/BPBM group (3.82 +/- 1.43 mm on buccal sites and 3.74 +/- 1.38 mm on lingual sites) as compared to the EMP group (1.33 +/1.17 mm on buccal sites and 1.41 +/- 1.19 mm on lingual sites).
The results of this study indicate that BPBM has the ability to augment the effects of EMPs in reducing probing depth, improving clinical attachment levels, and promoting defect fill when compared to presurgical levels.
研究表明，使用釉基质蛋白（EMPs）或牛多孔骨矿物质（BPBM）移植可实现骨内牙周缺损的临床改善。目前尚无关于EMPs与BPBM在牙周再生治疗中潜在协同作用的报道。本研究的目的是比较单独使用EMPs或与BPBM联合使用治疗人类牙周骨内缺损的临床效果。
采用分口设计对21对骨内缺损进行手术治疗。骨内缺损分别采用釉基质蛋白治疗（EMP组）或釉基质蛋白联合牛多孔骨矿物质治疗（EMP/BPBM组）。6个月时进行再次手术。
EMP组和EMP/BPBM组术前探诊深度、附着水平和术中骨测量结果相似。6个月时的术后测量显示，与EMP组（颊侧1.91±1.42mm，舌侧1.85±1.38mm）相比，EMP/BPBM组（颊侧3.43±1.32mm，舌侧3.36±1.35mm）的探诊深度显著降低。EMP/BPBM组的附着增加量（颊侧3.13±1.41mm，舌侧3.11±1.39mm）也显著高于EMP组（颊侧1.72±1.33mm，舌侧1.75±1.37mm）。对治疗后的缺损进行再次手术发现，与EMP组（颊侧1.33±1.17mm，舌侧1.41±1.19mm）相比，EMP/BPBM组（颊侧3.82±1.43mm，舌侧3.74±1.38mm）的缺损填充量显著增加。
本研究结果表明，与术前水平相比，BPBM能够增强EMPs在降低探诊深度、改善临床附着水平和促进缺损填充方面的作用。
Zotero 插件