靶向细胞周期G1期的新型抗肿瘤青蒿素衍生物。
Novel antitumor artemisinin derivatives targeting G1 phase of the cell cycle.
作者信息
Li Y, Shan F, Wu J M, Wu G S, Ding J, Xiao D, Yang W Y, Atassi G, Léonce S, Caignard D H, Renard P
机构信息
Department of Synthetic Chemistry, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.
出版信息
Bioorg Med Chem Lett. 2001 Jan 8;11(1):5-8. doi: 10.1016/s0960-894x(00)00578-3.
Modification of artemisinin structure led us to the discovery of a novel class of antitumor compounds. These artemisinin derivatives containing cyano and aryl groups showed potent antiproliferative effect in vitro against P388 and A549 cells. This activity was reflected in P388 murine leukemia by an accumulation of cells in G1 phase, and induction of apoptosis.
青蒿素结构的修饰使我们发现了一类新型抗肿瘤化合物。这些含有氰基和芳基的青蒿素衍生物在体外对P388和A549细胞显示出强大的抗增殖作用。这种活性在P388小鼠白血病中表现为细胞在G1期积累，并诱导细胞凋亡。
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