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Qinghaosu (artemisinin): chemistry and pharmacology.青蒿素（黄花蒿素）：化学与药理学。
Acta Pharmacol Sin. 2012 Sep;33(9):1141-6. doi: 10.1038/aps.2012.104. Epub 2012 Aug 27.
2
An over four millennium story behind qinghaosu (artemisinin)--a fantastic antimalarial drug from a traditional chinese herb.青蒿素背后跨越四千多年的故事——一种源自传统中草药的神奇抗疟药物。
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Recent advances in artemisinin and its derivatives as antimalarial and antitumor agents.青蒿素及其衍生物作为抗疟和抗肿瘤药物的最新进展。
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Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents.青蒿素及其衍生物：一类新型的抗疟和抗癌药物。
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How Chinese scientists discovered qinghaosu (artemisinin) and developed its derivatives? What are the future perspectives?中国科学家是如何发现青蒿素并研发其衍生物的？未来的前景如何？
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本文引用的文献

1
SM934 treated lupus-prone NZB × NZW F1 mice by enhancing macrophage interleukin-10 production and suppressing pathogenic T cell development.SM934 通过增强巨噬细胞白细胞介素-10 的产生和抑制致病性 T 细胞的发育来治疗狼疮易感 NZB × NZW F1 小鼠。
PLoS One. 2012;7(2):e32424. doi: 10.1371/journal.pone.0032424. Epub 2012 Feb 28.
2
Antitumor activity of artemisinin and its derivatives: from a well-known antimalarial agent to a potential anticancer drug.青蒿素及其衍生物的抗肿瘤活性：从一种著名的抗疟药物到一种潜在的抗癌药物。
J Biomed Biotechnol. 2012;2012:247597. doi: 10.1155/2012/247597. Epub 2011 Nov 22.
3
Characterization of dihydroartemisinin-resistant colon carcinoma HCT116/R cell line.二氢青蒿素耐药结肠癌细胞系 HCT116/R 的特征。
Mol Cell Biochem. 2012 Jan;360(1-2):329-37. doi: 10.1007/s11010-011-1072-2. Epub 2011 Sep 30.
4
Oral administration of artemisinin analog SM934 ameliorates lupus syndromes in MRL/lpr mice by inhibiting Th1 and Th17 cell responses.口服青蒿素类似物SM934通过抑制Th1和Th17细胞反应改善MRL/lpr小鼠的狼疮综合征。
Arthritis Rheum. 2011 Aug;63(8):2445-55. doi: 10.1002/art.30392.
5
The anti-cancer activity of dihydroartemisinin is associated with induction of iron-dependent endoplasmic reticulum stress in colorectal carcinoma HCT116 cells.双氢青蒿素的抗癌活性与诱导结直肠癌细胞 HCT116 中铁依赖性内质网应激有关。
Invest New Drugs. 2011 Dec;29(6):1276-83. doi: 10.1007/s10637-010-9481-8. Epub 2010 Jul 7.
6
The molecular mechanism of action of artemisinin--the debate continues.青蒿素的作用机制——争论仍在继续。
Molecules. 2010 Mar 12;15(3):1705-21. doi: 10.3390/molecules15031705.
7
Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation.青蒿素通过其特有的线粒体激活作用直接靶向疟原虫线粒体。
PLoS One. 2010 Mar 8;5(3):e9582. doi: 10.1371/journal.pone.0009582.
8
Dihydroartemisinin accelerates c-MYC oncoprotein degradation and induces apoptosis in c-MYC-overexpressing tumor cells.双氢青蒿素加速 c-MYC 癌蛋白降解并诱导 c-MYC 过表达肿瘤细胞凋亡。
Biochem Pharmacol. 2010 Jul 1;80(1):22-30. doi: 10.1016/j.bcp.2010.02.016. Epub 2010 Mar 3.
9
Subcellular localization of a fluorescent artemisinin derivative to endoplasmic reticulum.荧光青蒿素衍生物的亚细胞定位到内质网。
Org Lett. 2010 Apr 2;12(7):1420-3. doi: 10.1021/ol902890j.
10
Effect of artemisinin derivatives on apoptosis and cell cycle in prostate cancer cells.青蒿素衍生物对前列腺癌细胞凋亡和细胞周期的影响。
Anticancer Drugs. 2010 Apr;21(4):423-32. doi: 10.1097/CAD.0b013e328336f57b.

青蒿素（黄花蒿素）：化学与药理学。

Qinghaosu (artemisinin): chemistry and pharmacology.

机构信息

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China.

出版信息

Acta Pharmacol Sin. 2012 Sep;33(9):1141-6. doi: 10.1038/aps.2012.104. Epub 2012 Aug 27.

DOI:10.1038/aps.2012.104
PMID:22922345
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4003104/
Abstract

Qinghaosu and its derivatives are widely used in the world as a new generation of antimalarial drug. Up to now, some important progresses of Qinghaosu research have been made, including synthesis of new qinghaosu derivatives and analogs, investigation on their bioactivities and mode of actions. The present review briefly describes these efforts made by researchers in China, particularly in this Institute.

摘要

青蒿素及其衍生物在世界范围内广泛用作新一代抗疟药物。到目前为止，青蒿素的研究已经取得了一些重要进展，包括新的青蒿素衍生物和类似物的合成、它们的生物活性和作用模式的研究。本文简要描述了中国研究人员，特别是本研究所的研究人员在这方面所做的努力。