Gulumian M
National Centre for Occupational Health and Department of Haematology and Molecular Medicine, University of the Witwatersrand, Johannesburg, South Africa.
Redox Rep. 2000;5(6):325-51. doi: 10.1179/135100000101535906.
Exposure to pathogenic mineral dusts and fibres is associated with pulmonary changes including fibrosis and cancer. Investigations into aetiological mechanisms of these diseases have identified modifications in specific macromolecules as well as changes in certain early processes, which have preceded fibrosis and cancer. Peroxidation of lipids is one such modification, which is observed following exposure to mineral dusts and fibres. Their ability to initiate lipid peroxidation and the parameters that determine this ability have recently been reviewed. Part II of this review examines the relationship between the capacity of mineral dusts and fibres to initiate lipid peroxidation and a number of pathological changes they produce. The oxidative modification of polyunsaturated fatty acids is a major contributor to membrane damage in cells and has been implicated in a great variety of pathological processes. In most pathological conditions where an induction of lipid peroxidation is observed it is assumed to be the consequence of disease, without further establishing if the induction of lipid peroxidation may have preceded or accompanied the disease. In the great majority of instances, however, despite the difficulty in proving this association, a causal relationship between lipid peroxidation and disease cannot be ruled out.
接触致病性矿物粉尘和纤维与包括纤维化和癌症在内的肺部变化有关。对这些疾病病因机制的研究已经确定了特定大分子的修饰以及某些早期过程的变化，这些变化发生在纤维化和癌症之前。脂质过氧化就是这样一种修饰，在接触矿物粉尘和纤维后可以观察到。它们引发脂质过氧化的能力以及决定这种能力的参数最近已得到综述。本综述的第二部分研究了矿物粉尘和纤维引发脂质过氧化的能力与它们所产生的一些病理变化之间的关系。多不饱和脂肪酸的氧化修饰是细胞中膜损伤的主要原因，并且与多种病理过程有关。在大多数观察到脂质过氧化诱导的病理情况下，人们认为这是疾病的结果，而没有进一步确定脂质过氧化的诱导是否可能先于疾病或与疾病同时发生。然而，在绝大多数情况下，尽管难以证明这种关联，但脂质过氧化与疾病之间的因果关系不能排除。
