Tátrai E, Ungváry G, Adamis Z, Timár M
Exp Pathol. 1985;28(2):111-8. doi: 10.1016/s0232-1513(85)80022-0.
The effect of intratracheal introduction of different metal and mineral dusts and the change in activity of pulmonary acidic phosphatase have been studied as a function of time (72 h, 2 weeks, 1, 12, 20 months). The activity and localization of acid phosphatase were compared with the degree of pulmonary damage caused by dusts. The degree of fibrosis was determined on the basis of the composition of cells and fibres, according to Belt and King's classification. Due to the membrane-damaging effect of DQ 12 silica and mixed dusts (enargite and porphyry rock dusts) an increase in acid phosphatase activity of macrophages could be observed at the end of the first month. At the same time non-fibrogenic or only mild fibrogenic dusts (bentonite, corundum, scarnic rock dust) caused a decrease or disappearance of tissue acid phosphatase activity. It has been stated that there is a very close correlation between the change in pulmonary acidic phosphatase activity and the progression of pulmonary fibrosis due to exposure to mineral dusts. The above investigations have been most useful in predicting the subsequent effect of rock patterns, emphasizing at the same time the importance of in vivo long term experiments.
研究了气管内注入不同金属和矿物粉尘的效果以及肺酸性磷酸酶活性随时间（72小时、2周、1个月、12个月、20个月）的变化。将酸性磷酸酶的活性和定位与粉尘引起的肺损伤程度进行了比较。根据Belt和King的分类，基于细胞和纤维的组成确定纤维化程度。由于DQ 12二氧化硅和混合粉尘（硫砷铜矿和斑岩岩尘）的膜损伤作用，在第一个月末可观察到巨噬细胞酸性磷酸酶活性增加。同时，非纤维化或仅轻度纤维化的粉尘（膨润土、刚玉、斯卡尼克岩尘）导致组织酸性磷酸酶活性降低或消失。已经表明，肺酸性磷酸酶活性的变化与因接触矿物粉尘导致的肺纤维化进展之间存在非常密切的相关性。上述研究对于预测岩石类型的后续影响非常有用，同时强调了体内长期实验的重要性。
