Harrison J D, Fouad H M, Garrett J R
Department of Oral Pathology, Guy's, King's and St Thomas's Dental Institute, London, England.
J Oral Pathol Med. 2001 Jan;30(1):29-34. doi: 10.1034/j.1600-0714.2001.300105.x.
A variable response following ductal ligation of feline salivary glands corresponds to the human condition but contrasts with a predictable atrophy in obstructed salivary glands of rodents popularly used as a model for human salivary problems. The present investigation is concerned with a possible reason for the variable response, namely the preservation of the innervation. Ducts of feline submandibular and sublingual salivary glands were ligated with or without the inclusion of the chorda tympani. Inclusion led to a delayed initial response followed by progressive atrophy until the parenchyma was extremely atrophic, whereas avoidance of the chorda led to the variable response in which variable numbers of acini of a similar form to normal persisted. The results establish the atrophic effect of inclusion of the chorda tympani in ductal ligation and indicate the caution that should be exercised in the extrapolation of the rodent model to the human condition.
猫唾液腺导管结扎后的可变反应与人类情况相符，但与常用作人类唾液问题模型的啮齿动物阻塞性唾液腺中可预测的萎缩形成对比。本研究关注这种可变反应的一个可能原因，即神经支配的保留。猫下颌下和舌下唾液腺的导管在包含或不包含鼓索神经的情况下进行结扎。包含鼓索神经会导致初始反应延迟，随后逐渐萎缩，直到实质极度萎缩，而避开鼓索神经则会导致可变反应，其中数量不等的形态与正常相似的腺泡持续存在。这些结果证实了在导管结扎中包含鼓索神经的萎缩效应，并表明在将啮齿动物模型外推至人类情况时应谨慎行事。
