从冲绳软珊瑚科氏指形软珊瑚中分离得到的新型海松烷型二萜类化合物。
New marine cembrane-type diterpenoids from the Okinawan soft coral Clavularia koellikeri.
作者信息
Iwashima M, Matsumoto Y, Takahashi H, Iguchi K
机构信息
Laboratory of Bioorganic Chemistry, School of Life Science, Tokyo University of Pharmacy and Life Science, Horinouchi, Hachioji, Tokyo 192-0392, Japan.
出版信息
J Nat Prod. 2000 Dec;63(12):1647-52. doi: 10.1021/np000309w.
Seven new marine diterpenoids having a cembrane skeleton were isolated from the Okinawan soft coral Clavularia koellikeri. Their structures were determined based on the results of spectroscopic analysis and chemical conversions. Compound 1 showed cytotoxic activity against human colorectal adenocarcinoma cells (DLD-1, IC(50) 4.2 g/mL) and strong growth inhibition against human T lymphocytic leukemia cells (MOLT-4, IC(50) 0.9 g/mL).
从冲绳软珊瑚科氏指形软珊瑚（Clavularia koellikeri）中分离出七种具有西松烷骨架的新型海洋二萜类化合物。根据光谱分析和化学转化结果确定了它们的结构。化合物1对人结肠直肠腺癌细胞（DLD-1，半数抑制浓度（IC50）为4.2微克/毫升）显示出细胞毒性活性，对人T淋巴细胞白血病细胞（MOLT-4，半数抑制浓度（IC50）为0.9微克/毫升）具有强烈的生长抑制作用。
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