Iwashima M, Matsumoto Y, Takahashi H, Iguchi K
Laboratory of Bioorganic Chemistry, School of Life Science, Tokyo University of Pharmacy and Life Science, Horinouchi, Hachioji, Tokyo 192-0392, Japan.
J Nat Prod. 2000 Dec;63(12):1647-52. doi: 10.1021/np000309w.
Seven new marine diterpenoids having a cembrane skeleton were isolated from the Okinawan soft coral Clavularia koellikeri. Their structures were determined based on the results of spectroscopic analysis and chemical conversions. Compound 1 showed cytotoxic activity against human colorectal adenocarcinoma cells (DLD-1, IC(50) 4.2 g/mL) and strong growth inhibition against human T lymphocytic leukemia cells (MOLT-4, IC(50) 0.9 g/mL).
从冲绳软珊瑚科氏指形软珊瑚（Clavularia koellikeri）中分离出七种具有西松烷骨架的新型海洋二萜类化合物。根据光谱分析和化学转化结果确定了它们的结构。化合物1对人结肠直肠腺癌细胞（DLD-1，半数抑制浓度（IC50）为4.2微克/毫升）显示出细胞毒性活性，对人T淋巴细胞白血病细胞（MOLT-4，半数抑制浓度（IC50）为0.9微克/毫升）具有强烈的生长抑制作用。
