来自台湾软珊瑚厚轴肉芝软珊瑚的细胞毒性松节内酯和甾体化合物。

Cytotoxic cembrenolides and steroids from the formosan soft coral Sarcophyton crassocaule.

作者信息

Duh C Y, Wang S K, Chung S G, Chou G C, Dai C F

机构信息

Department of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.

出版信息

J Nat Prod. 2000 Dec;63(12):1634-7. doi: 10.1021/np0002381.

DOI:10.1021/np0002381

PMID:11141104

Abstract

Three new cytotoxic cembrenolide diterpenes, sarcocrassolide (1), crassolide (2), and 13-acetoxysarcocrassolide (3); a known cytotoxic cembrenolide, denticulatolide (4); and two cytotoxic steroids, (24S)-24-methylcholestane-3beta,5alpha,6beta-triol (5) and 24zeta-methylcholestane-3beta,5alpha,6beta,25-te traol-25-monoacetate (6), have been isolated from the Formosan soft coral Sarcophyton crassocaule. The structures of compounds 1-6 were determined by 1D and 2D spectral analysis.

摘要

从台湾软珊瑚厚丛肉芝软珊瑚中分离出三种新的具有细胞毒性的西松烷型二萜类化合物，即厚丛肉芝内酯（1）、肉芝内酯（2）和13-乙酰氧基厚丛肉芝内酯（3）；一种已知的具有细胞毒性的西松烷型二萜类化合物，细齿肉芝内酯（4）；以及两种具有细胞毒性的甾体化合物，（24S）-24-甲基胆甾烷-3β，5α，6β-三醇（5）和24ζ-甲基胆甾烷-3β，5α，6β，25-四醇-25-单乙酸酯（6）。通过一维和二维光谱分析确定了化合物1-6的结构。