Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan.
Mar Drugs. 2011;9(6):994-1006. doi: 10.3390/md9060994. Epub 2011 Jun 9.
Seven new cembranoids, sarcocrassocolides F-L (1-7), have been isolated from a soft coral Sarcophyton crassocaule. Their structures were determined by extensive spectroscopic analysis. Most new compounds exhibited significant cytotoxic activity against a limited panel of cancer cell lines, and the structure-activity relationship was studied. Compounds 1-7 were found to display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Compound 4 was also found to effectively reduce the level of COX-2 protein.
从软珊瑚 Sarcophyton crassocaule 中分离得到了 7 种新的海鞘烷类化合物 sarcocrassocolides F-L（1-7）。通过广泛的光谱分析确定了它们的结构。大多数新化合物对有限的癌细胞系表现出显著的细胞毒性活性，并研究了结构-活性关系。化合物 1-7 通过抑制 iNOS 蛋白的表达，在 LPS 刺激的 RAW264.7 巨噬细胞中表现出显著的体外抗炎活性。还发现化合物 4 能有效降低 COX-2 蛋白的水平。
