Shaikh B, Chu P S
Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, Maryland 20708, USA.
J Agric Food Chem. 2000 Dec;48(12):6404-8. doi: 10.1021/jf000519e.
The distribution of total 14C residues was studied in egg yolk and albumen after administration of either single or multiple oral dosages of [14C]sulfamethazine (SMZ). One day after a single dose of [14C]SMZ (121 mg of sulfamethazine, 2.42 x 10(7) dpm), the 14C residue concentration peaked in egg albumen and egg yolk with the concentration in the former >4-fold greater than in the latter. Three days postdose, the 14C residue concentration in the yolk was approximately 7-fold higher than in the egg albumen. A multiple dose of [14C]SMZ containing sulfamethazine mass equivalent of an average therapeutic dose (282 mg, 2.9 x 10(7) dpm) for chickens was also administered orally for six consecutive days to hens. A significantly reduced level of egg production was observed during the medication, and most of the hens stopped laying eggs after the last dose. The 14C residue concentrations peaked on the last day (sixth) of medication in egg albumen and yolk. The 14C residue concentrations were also measured in liver, muscle, blood, and plasma of chickens sacrificed at 1, 24, 48, and 72 h after the last dose. Highest concentrations of 14C residue were accumulated in liver followed by, in decreasing order, blood, plasma, and muscle.
在给予单次或多次口服剂量的[¹⁴C]磺胺二甲嘧啶（SMZ）后，研究了¹⁴C总残留量在蛋黄和蛋清中的分布情况。单次给予[¹⁴C]SMZ（121毫克磺胺二甲嘧啶，2.42×10⁷ 每分钟衰变数）一天后，蛋清和蛋黄中的¹⁴C残留浓度达到峰值，前者的浓度比后者高4倍以上。给药后三天，蛋黄中的¹⁴C残留浓度比蛋清高约7倍。还对母鸡连续六天口服多次剂量的[¹⁴C]SMZ，其磺胺二甲嘧啶质量相当于鸡的平均治疗剂量（282毫克，2.9×10⁷ 每分钟衰变数）。在用药期间观察到产蛋量显著下降，大多数母鸡在最后一剂后停止产蛋。¹⁴C残留浓度在用药的最后一天（第六天）在蛋清和蛋黄中达到峰值。在最后一剂后1、24、48和72小时处死的鸡的肝脏、肌肉、血液和血浆中也测量了¹⁴C残留浓度。¹⁴C残留浓度最高积聚在肝脏中，其次按降序排列为血液、血浆和肌肉。
