Geertsma M F, Nouws J F, Grondel J L, Aerts M M, Vree T B, Kan C A
Vet Q. 1987 Jan;9(1):67-75. doi: 10.1080/01652176.1987.9694077.
The depletion of sulphadimidine (SDM) and its N4-acetyl and hydroxy metabolites was studied in eggs laid by hens after administration of either a single or multiple oral dosages of 100 mg SDM/kg. During medication and until 1 day after the last dose, the SDM and its metabolite concentrations in the egg white exceeded those in the egg yolk and reflected the plasma levels. In the period starting 2 days after the (last) dosage, the SDM concentration in the yolk became higher than in the egg white, and the drug depletion curves ran parallel. The mean maximum amount of SDM found in the whole egg was 1500 micrograms after a single and 1280 micrograms after multiple dosage. In eggs, traces of the N4-acetyl and 6-methylhydroxy metabolites could be detected (mainly in the egg white), and their concentrations were approximately 40 times lower than those of the parent drug. A highly significant correlation (P less than 0.005) was found between the development stage of the oocyte at the time of (last) medication and the amount of SDM found in the egg that developed from it. A period of 7 or 8 days after the (last) dosage of 100 mg SDM/kg/day is required to obtain SDM levels below 0.1 micrograms/g egg.
研究了母鸡单次或多次口服100毫克磺胺二甲嘧啶（SDM）/千克后所产鸡蛋中SDM及其N4-乙酰和羟基代谢物的消耗情况。在用药期间以及最后一剂后的1天内，蛋清中SDM及其代谢物的浓度超过蛋黄中的浓度，并反映了血浆水平。在（最后）给药后2天开始的时间段内，蛋黄中SDM的浓度高于蛋清中的浓度，且药物消耗曲线平行。单次给药后全蛋中SDM的平均最大含量为1500微克，多次给药后为1280微克。在鸡蛋中可检测到痕量的N4-乙酰和6-甲基羟基代谢物（主要在蛋清中），其浓度比母体药物低约40倍。在（最后）用药时卵母细胞的发育阶段与由此发育而来的鸡蛋中SDM的含量之间发现高度显著的相关性（P小于0.005）。要使鸡蛋中SDM水平低于0.1微克/克，需要在（最后）以100毫克SDM/千克/天的剂量给药后7或8天。
